FX-11

Products

Quote Request

Catalog No.: PC0064

Size: 5 mg,10 mg, 25 mg,50 mg, 100 mg, 200 mg, 500 mg

Description

FX-11 is a potent, selective, reversible, competitive inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production, and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts.

Molecular Weight	350.41
Formula	C22H22O4
CAS No.	213971-34-7
Appearance	Solid
Color	White to off-white
SMILES	O=C(C1=C2C=C(CC3=CC=CC=C3)C(C)=CC2=C(CCC)C(O)=C1O)O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vitro*	FX-11 (9 μM, 24-48 h) shows activation of AMP kinase and phosphorylation of its substrate acetyl-CoA carboxylase. FX-11 (0-100 μM, 72 h) inhibits cell proliferation in BxPc-3 and MIA PaCa-2 cells. FX-11 inhibits glycolysis and alters cellular energy metabolism in P493 cells.
*In Vivo*	FX-11 (42 μg/mouse; IP, daily for 10-14 days) inhibits P493 tumor growth. FX-11 (0-2 mg/kg, IP, daily, for 3 weeks) significantly delays tumor growth.

All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.