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FX-11

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FX-11

FX-11

Catalog No.: PC0064

Size: 5 mg,10 mg, 25 mg,50 mg, 100 mg, 200 mg, 500 mg

Description

FX-11 is a potent, selective, reversible, competitive inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production, and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts.

Molecular Weight 350.41
Formula C22H22O4
CAS No. 213971-34-7
Appearance Solid
Color White to off-white
SMILES O=C(C1=C2C=C(CC3=CC=CC=C3)C(C)=CC2=C(CCC)C(O)=C1O)O
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
In Vitro FX-11 (9 μM, 24-48 h) shows activation of AMP kinase and phosphorylation of its substrate acetyl-CoA carboxylase.
FX-11 (0-100 μM, 72 h) inhibits cell proliferation in BxPc-3 and MIA PaCa-2 cells.
FX-11 inhibits glycolysis and alters cellular energy metabolism in P493 cells.
In Vivo FX-11 (42 μg/mouse; IP, daily for 10-14 days) inhibits P493 tumor growth.
FX-11 (0-2 mg/kg, IP, daily, for 3 weeks) significantly delays tumor growth.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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