In Vivo PK Services

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As a reliable partner to top pharmaceutical companies and research institutions worldwide, Alfa Cytology provides expertise in pharmacokinetics (PK) study at all stages of research and development. We have extensive experience designing, executing, and interpreting the results of PK studies across multiple species.

Overview of In Vivo PK

PK factors, such as drug absorption, distribution, metabolism, and elimination (ADME), limit the drug amount the system delivers to reach the tumor. The anticancer activity of a drug may be limited by insufficient inflow or excessive efflux. Choosing the right in vivo PK model and the study design protocol to measure the therapy efficacy are critical steps in translating preclinical drug candidates into effective treatments. Pharmacokinetic studies provide essential and useful information for therapy development and optimization, such as determining drug bioavailability, metabolic time, etc.

Pharmacokinetics are important factors that limit the amount of drug that reaches the tumor. Fig. 1 Relationship between PK and drug resistance. (Holohan, C.; et al., 2013)

Our Services

In vivo PK studies provide a clear and unique explanation for understanding the action and behavior of drugs in vivo, providing a wealth of critical information before clinical trials. Alfa Cytology offers an all-in-one in vivo PK service to support the development of therapy candidates.

In Vivo PK

In vivo, PK studies characterize compounds, understand their significance, support pharmacology and toxicology, and optimize drug candidates. The relevant parameters include AUC_0-t, C_max, T_max, t_1/2, Kel, Ka-tumor, and Kd-tumor.

Pharmacokinetics in Blood or Tumor
Toxicokinetic Study
Multisite Drug Concentration

In Vivo ADME
Dose-Response Assessment
PK Parameter Analysis

Animal Models and Species

PK is usually detected using normal animal models, but can also be detected in cancer models. Our in vivo PK service covers a comprehensive range of animal models across multipsle species and can be performed with pharmacodynamic testing.

Model Types

Model Species

Mouse
Rat
Hamster
Mini Pig
Rabbit
Beagle
Guinea Pig
Cynomolgus Monkey

Route of Administration

Different routes of administration can greatly affect the pharmacokinetic results. Alfa Cytology provides multiple routes of administration.

Oral
Intramuscular
Intraperitoneal

Intravenous
Intraduodenal
Inhalation

Subcutaneous
Portal vein
And more...

Why Choose Us?

Customized solution Highly-experienced expert team Variety of preclinical models Quick turnaround time Worldwide service

Alfa Cytology has advanced technology and diverse research models to ensure accurate and comprehensive analysis of in vivo PK. We work closely with our customers to tailor projects to specific research needs, contributing to pancreatic cancer therapy development. Please contact us for more information about our services.

Reference

Holohan, C., et al. Cancer drug resistance: an evolving paradigm. Nat Rev Cancer. 2013;13(10):714-726. doi:10.1038/nrc3599

All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.