LP-184

Products

Catalog No.: PC0103

Size: 1 mg,5 mg, 10 mg, 50mg

LP-184 is an acylfulvene analog that inhibits tumor growth and has potent anticancer activity in ovarian, colon, prostate and pancreatic cell lines.

Molecular Weight	304.34
Formula	C16H20N2O4
CAS No.	924835-67-6
Appearance	Solid
Color	Light yellow to yellow
SMILES	CC(C1(CC1)[C@@](O)(C2=O)C)=C3C2=CC(C)=C3CN(O)C(N)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vitro*	LP-184 inhibits the growth of HT29, OVCAR-3, AsPC-1 and PC-3, with GI50s of 0.68, 0.6, 16 and 0.14 μM, respectively. LP-184 displays IC₅₀s of 800nM and 210 nM for anti-cancer activitie in the thymidine incorporation into cellular DNA (2 hour) and Trypan blue (48 hour) assay.
*In Vivo*	LP-184 (7.5 and 10 mg/kg; i.p.; 21 day) has potent 15 anti-tumor activity against MV522 tumors, producing 4/6 and 5/5 partial responses, respectively.

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