Molecular Weight |
304.34 |
Formula |
C16H20N2O4 |
CAS No. |
924835-67-6 |
Appearance |
Solid |
Color |
Light yellow to yellow |
SMILES |
CC(C1(CC1)[C@@](O)(C2=O)C)=C3C2=CC(C)=C3CN(O)C(N)=O |
Shipping |
Room temperature in continental US; may vary elsewhere. |
Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
In Vitro |
LP-184 inhibits the growth of HT29, OVCAR-3, AsPC-1 and PC-3, with GI50s of 0.68, 0.6, 16 and 0.14 μM, respectively. LP-184 displays IC50s of 800nM and 210 nM for anti-cancer activitie in the thymidine incorporation into cellular DNA (2 hour) and Trypan blue (48 hour) assay. |
In Vivo |
LP-184 (7.5 and 10 mg/kg; i.p.; 21 day) has potent 15 anti-tumor activity against MV522 tumors, producing 4/6 and 5/5 partial responses, respectively. |