| Molecular Weight |
585.22 |
| Formula |
C36H45ClN4O |
| CAS No. |
104264-80-4 |
| Appearance |
Solid |
| Color |
Light yellow to brown |
| SMILES |
O[C@]1(CC/C=C\CCCC2)[C@@]3([H])[C@@](C[C@@]4([H])N3CCCC/C=C\4)(C[N@@]2CC5)[C@]5([H])C(C6=C(NC7=CC=CC=C87)C8=CC=N6)=C1.Cl |
| Shipping |
Room temperature in continental US; may vary elsewhere. |
| Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| In Vitro |
Manzamine A (5-50 µM, 18 h) hydrochloride decreases tau phosphorylation, measured with ELISA.
Manzamine A (10 µM) hydrochloride inhibits yeast S. cerevisiae growth by 30%.
Manzamine A hydrochloride displays a few enlarged vacuoles in yeast.
Manzamine A (2.5-10 µM, 24 h) hydrochloride increases acidity in pancreatic cancer cells and non-malignant Vero cells.
Manzamine A (1 µM, 24 h) hydrochloride inhibits HSV-1 infection in SIRC cells.
Manzamine A hydrochloride shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone). |
| In Vivo |
Manzamine A (50 and 100 mol/kg, p.o. or i.p.) hydrochloride inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice.
Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) hydrochloride prolongs the survival of SW mice to 20 days. |
