Pancreatic cancer is a relatively common digestive system tumor with a high degree of malignancy. More than half of PCs are located in the head of the pancreas, and about 90% are ductal adenocarcinomas originating from the ductal epithelium. The five-year survival rate after PC is diagnosed is about 10%, and it is one of the malignant tumors with the worst prognosis. Therefore, new effective therapies are urgently needed to improve the low survival rate of patients with advanced PC. PC patients require continued targeted chemotherapy. Tumor cells isolated from human tissues can be used to predict patients' response to chemotherapy and can also be used in the pathogenesis of PC and the development of drugs and therapies.
Pancreatic Cancer Cell Lines We Offer
Pancreatic cancer may originate from the exocrine or endocrine compartment of the pancreas, and most of them are exocrine tumors, divided into ductal adenocarcinoma and acinar adenocarcinoma; endocrine tumors are mainly pancreatic neuroendocrine tumors. There are differences between exocrine and endocrine tumors, and Alfa Cytology can select the most appropriate cell line for you.
Alfa Cytology is a leading global life sciences company. We have in-depth knowledge of PC units and other components. Here, we are committed to providing diverse cell lines for PC research and development of successful treatment options. If you are interested in our services, please feel free to contact us. We will provide professional and competitively priced solutions tailored to your needs.
PSN1
Origin: Human pancreatic adenocarcinoma
Description: The human pancreatic cancer cell line PSN1 is derived from pancreatic adenocarcinoma tissue. After transplantation into nude mice, a PSN1 cell line was established from the xenografts. PSN1 cells are unique in that c-myc and activated c-Ki-ras are expanded to the same extent as PSN1 cells. Primitive tumors and contained increased amounts of c-myc and c-Ki-ras transcripts. Loss of one of the two p53 alleles and a point mutation from AAG to CAG at codon 132 in the remaining allele were also observed in PSN1.