PIK-75

Products

Quote Request

Catalog No.: PC0162

Size: 50 mg, 100mg, 250mg

Description

PIK-75 is a reversible DNA-PK and p110α-selective inhibitor of DNA-PK, p110α, and p110γ with IC₅₀ of 2, 5.8, and 76 nM, respectively. The ability of PIK-75 to inhibit p110α is more than 200 times that of p110β (IC₅₀=1.3 μM) and induce apoptosis.

Molecular Weight	452.28
Formula	C16H14BrN5O4S
CAS No.	372196-67-3
SMILES	O=S(C1=CC([N+]([O-])=O)=CC=C1C)(N(C)/N=C/C2=CN=C3C=CC(Br)=CN32)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vivo*	PIK-75 (2 mg/kg) potentiates anticancer activity of Gemcitabine (20 mg/kg) in vivo. Gemcitabine (20 mg/kg) or PIK-75 (2 mg/kg) alone reduces the tumor growth to similar degree. Beneficial effect of PIK-75/Gemcitabine is evident as this combination markedly reduces the tumor growth in vivowithout affecting the body weights of mice.

All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.