PKI-166 hydrochloride

Products

Catalog No.: PC0154

Size: 5 mg, 10 mg, 25 mg,50 mg, 100 mg, 200 mg, 500 mg

PKI-166 hydrochloride is a potent, selective and orally active EGFR tyrosine kinase inhibitor, with an IC₅₀ of 0.7 nM.

Molecular Weight	366.84
Formula	C20H19ClN4O
CAS No.	2230253-82-2
SMILES	OC1=CC=C(C2=CC3=C(N=CN=C3N2)N[C@H](C)C4=CC=CC=C4)C=C1.Cl[H]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vitro*	PKI-166 hydrochloride (0-0.5 μM; 1 hour; pretreatment) inhibits EGFR autophosphorylation in human pancreatic cancer cells. PKI-166 hydrochloride (0.03 μM; 6 days) enhances the cytotoxicity mediated by gemcitabine.
*In Vivo*	PKI-166 hydrochloride (100 mg/kg; p.o.; daily; for 29 days) inhibits of pancreatic cancer growth.

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