PSN1

Products

Quote Request

Catalog No.: PC0002

Description

Human pancreatic cancer cell line PSN1 was derived from pancreatic adenocarcinoma tissue. After transplantation into nude mice, a PSN1 cell line was established from the xenografts. What is unique about PSN1 cells is the extent of amplification of c-myc (50-fold) and activated c-Ki-ras (3-6-fold) with a point mutation from GGT to CGT at codon 12 Same as PSN1 cells. Primitive tumors and contained increased amounts of c-myc and c-Ki-ras transcripts. Loss of one of the two p53 alleles and a point mutation from AAG to CAG at codon 132 in the remaining allele were also observed in PSN1.

Origin	Human pancreatic adenocarcinoma
Application	PSN1 has been used in in vitro studies to synthesize acetyl homoagmatine. It is also used to determine the cytotoxicity of irinotecan and topotecan. PSN1 is an example of a cancer cell that harbors multiple genetic changes, including two oncogenes (c-Ki-ras and c-myc) and a tumor suppressor gene (p53).
Biological Source	Human pancreas
Growth Mode	Adherent
Karyotype	Not specified
Morphology	Epithelial
Products	Not specified
Receptors	Not specified
Technique	Cell culture, suitable for mammals.
Relevant Disease	Cancer
Shipped In	Dry ice
Culture Medium	RPMI 1640 + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).

All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.