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PSN1

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PSN1

Catalog No.: PC0021

Description

The human pancreatic cancer cell line PSN1 is derived from pancreatic adenocarcinoma tissue. After transplantation into nude mice, a PSN1 cell line was established from the xenografts. PSN1 cells are unique in that c-myc and activated c-Ki-ras are expanded to the same extent as PSN1 cells. Primitive tumors and contained increased amounts of c-myc and c-Ki-ras transcripts. Loss of one of the two p53 alleles and a point mutation from AAG to CAG at codon 132 in the remaining allele were also observed in PSN1.

Origin Human pancreatic adenocarcinoma
Application PSN1 has been used in vitro to study the synthesis of acetylhomogenetine. It is also used to determine the cytotoxicity of irinotecan and topotecan. PSN1 is an example of a cancer cell that harbors multiple genetic changes, including two oncogenes (c-Ki-ras and c-myc) and a tumor suppressor gene (p53).
Biological Source Human pancreas
Growth Mode Adherent
Karyotype Not specified
Morphology Epithelial
Products Not specified
Receptors Not specified
Technique Cell culture, suitable for mammals.
Relevant Disease Cancer
Shipped In Dry ice
Culture Medium RPMI 1640 + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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