RIN-m

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Catalog No.: PC0017

Description

Established from transplantable pancreatic tumors in the islets of Langerhans. The tumor originated in irradiated NEDH-suppressed albino rats and was maintained by serial transplantation of Nedh rats. The cell line RIN-m was established from the fourth nude mouse xenograft after transplantation into athymic nude mice, and 9 days after tumor resection, the cells were exposed to cystine-free medium, resulting in complete elimination of fibroblasts. RIN-m cells secrete insulin and somatostatin. High levels of levodopa decarboxylase and membrane-bound secretory granules were detected. RIN-5F (95090402) was established as a secondary clone of RIN-m.

Origin	Rat islet cell tumour
Application	Study of biology of pancreatic islet cells, synthesis, storage and secretion of insulin and somatostatin
Biological Source	Rat pancreas
Growth Mode	Adherent
Karyotype	Not specified
Morphology	Epithelial-like
Products	Somatostatin, insulin
Receptors	Not specified
Technique	Cell culture, suitable for mammals.
Relevant Disease	Cancer
Shipped In	Dry ice
Culture Medium	RPMI 1640 + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).

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