SHP2-IN-9

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Catalog No.: PC0179

Size: 5 mg, 10 mg, 25 mg,50 mg, 100 mg, 200 mg, 500 mg

Description

SHP2-IN-9 is a specific SHP2 inhibitor with enhanced blood-brain barrier permeability. SHP2-IN-9 inhibits SHP2-mediated cell signaling and cancer cell proliferation and inhibits cervical cancer tumor and glioblastoma growth in vivo.

Molecular Weight	385.46
Formula	C20H20FN3O2S
Appearance	Solid
Color	White to off-white
SMILES	O=C(NCC1=CC=C(C=C1)F)CN2C=NC3=C(C4=C(S3)CCCCC4)C2=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vitro*	SHP2-IN-9 (compound 2) could effectively inhibit SHP2-mediated cell signaling pathways in cancer (cervix cancer, human pancreatic cancer, large cell lung cancer and mouse glioma cell) by inhibiting the phosphorylation of Paxillin, affecting the regulation of the PI3K/AKT pathway and cell proliferation by causing the cell cycle arrest and inducing the early apoptosis.

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