Sophoridine

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Catalog No.: PC0102

Size: 5 mg,10 mg, 20 mg,50 mg, 100 mg

Description

Sophoridine is a quinolizidine alkaloid isolated from the leguminous plant Sophora flavescens and induces apoptosis. Sophoridine has the potential to become a new, effective, and selective anti-tumor drug candidate for pancreatic cancer with good toxicity tolerance.

Molecular Weight	248.36
Formula	C15H24N2O
CAS No.	6882-68-4
Appearance	Solid
Color	White to off-white
SMILES	O=C1CCC[C@]2([H])[C@@]3([H])CCCN4[C@@]3([H])[C@@](CCC4)([H])CN21
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vitro*	Sophoridine (0-500 μM; 48 hours) exhibits remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC₅₀ values of about 20 μM to 200 μM. Sophoridine (0-20 μM; 48 hours) increases S phase cell population from 26.23% (control) to 38.67% in Miapaca-2 cells and from 29.56% (control) to 39.16% in PANC-1 cells, about a 1.5-fold and a 1.3-fold increase, respectively. Sophoridine (0-20 μM; 48 hours) significantly increases bad and bax levels, and decreases bcl-2 and bcl-xl levels in contrast, with a significant increase in Bax/Bcl-2 ratio.
*In Vivo*	Sophoridine (intraperitoneal injection; 20 or 40 mg/kg; 21 days) can inhibit the growth of xenograft pancreatic tumors.

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