SP-141

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Catalog No.: PC0030

Size: 5 mg,10 mg, 25 mg,50 mg, 100 mg, 200 mg, 500 mg

Description

SP-141 is a specific inhibitor of MDM2. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 might be used for the research of pancreatic cancer and breast cancer cells.

Molecular Weight	324.38
Formula	C22H16N2O
CAS No.	1253491-42-7
Appearance	Solid
Color	Light yellow to yellow
SMILES	COC1=CC2=C(NC3=C2C=CN=C3C4=C5C=CC=CC5=CC=C4)C=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vitro*	SP-141 (0.01-10 μM; 72 hours) inhibits human pancreatic cancer cell growth with IC₅₀ values of less than 0.5 μM (0.38-0.50 μM) in a p53-independent manner. The IMR90 cells are much less sensitive to SP141 than the pancreatic cancer cells, suggesting that SP141 has a selective cytotoxicity for cancer cells. SP141 induces MDM2 auto-ubiquitination and proteasomal degradation in both HPAC and Panc-1 cells.
*In Vivo*	SP-141 (40 mg/kg; administered by i.p. injection; 5 d/wk for about three weeks) suppresses pancreatic tumor growth in both xenograft and orthotopic mouse models.

All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.