Stem cell therapy represents a promising frontier in the treatment of pancreatic cancer (PC). This approach aims to harness the regenerative potential of stem cells to target and eradicate pancreatic cancer cells. Alfa Cytology's stem cell therapy development services focus on advancing preclinical research to explore and refine these innovative treatments.
Overview of Stem Cell Therapy for Pancreatic Cancer
Stem cells have attracted widespread attention for their ability to localise tumours and are considered a promising approach for the treatment of pancreatic cancer due to their ability to enhance the ability to specify targets in mutated genes. Despite this, the clinical success of stem cell-based anti-cancer drugs under the current phase is very limited. Only a deeper understanding of the complex molecular biology behind pancreatic cancer and the subsequent identification of cancer stem cells as novel targets that promote cancer growth and chemotherapy resistance will lead to the most effective stem cell-mediated therapeutic options.
Fig. 1 Major signalling cascades in normal stem cells and pancreatic cancer stem cells and their therapeutic strategies. (Barman S, et al, 2021)
Currently, there are no approved stem cell drugs specifically targeting pancreatic cancer. However, research is being conducted into the potential use of stem cell therapies. These experimental therapies are still undergoing trials to determine their safety and efficacy. Some notable examples include:
| ClinicalTrials.gov ID | Sponsor | Study Title | Phase |
|---|---|---|---|
| NCT02207985 | Karolinska Institutet | Allogeneic Hematopoietic Stem Cell Transplantation in Pancreatic Adenocarcinoma | Phase I/II |
| NCT04150042 | General Oncology, Inc. | SHARON: A Clinical Trial for Metastatic Cancer With a BRCA or PALB2 Mutation Using Chemotherapy and Patients' Own Stem Cells | Phase I |
| NCT03236883 | Tianjin Medical University Cancer Institute and Hospital | Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of Pancreatic Cancer (HST) | / |
Our Services
Alfa Cytology offers a comprehensive, one-stop service for stem cell therapy development against pancreatic cancer. This service includes everything from initial cell isolation and characterization to preclinical testing and optimization. We aim to elucidate the mechanisms by which stem cells target and destroy pancreatic cancer cells and to develop effective stem cell-based therapies.
Stem Cell Therapy Development
Alfa Cytology aims to investigate the complex molecular biological mechanisms of pancreatic cancer and to develop effective therapies targeting pancreatic tumors by exploiting the unique properties of different types of stem cells listed below.
Mesenchymal Stem Cell Therapy
Utilizing MSCs for their ability to home in on tumor sites and deliver therapeutic agents.
Induced Pluripotent Stem Cell Therapy
iPSCs are reprogrammed cells that can be differentiated into various cell types for targeted therapy.
Hematopoietic Stem Cell Therapy
Involving the use of stem cells that can differentiate into blood cells to support cancer treatment.
Neural Stem Cell Therapy
Targeting and treating pancreatic cancer using the migratory properties of neural stem cells.
Our Technologies
Alfa Cytology has state-of-the-art tools and methodologies to develop and improve stem cell-based therapies to ensure precise targeting and enhanced efficacy, with the aim of overcoming the limitations of traditional treatments and providing innovative solutions for pancreatic cancer.
- CRISPR/Cas9 Gene Editing
- Next-Generation Sequencing (NGS)
- Real-Time Imaging Techniques
- 3D Bioprinting
- Single-Cell RNA Sequencing
- AI and Machine Learning
- Nanotechnology-Based Drug Delivery Systems
- High-Throughput Screening
Alfa Cytology specialises in the development of stem cell therapies for pancreatic cancer research. The services include the isolation, characterisation and differentiation of various stem cell types, as well as the design and execution of in vitro and in vivo experiments to assess their therapeutic potential. For more information or to establish a partnership, please contact us directly.
Reference
- Barman S, et al. Pancreatic Cancer and Therapy: Role and Regulation of Cancer Stem Cells. International Journal of Molecular Sciences. 2021, 22(9):4765.
