Sulfopin

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Catalog No.: PC0169

Size: 5 mg, 10 mg, 25 mg,50 mg, 100 mg, 200 mg, 500 mg

Description

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. The peptidylprolyl isomerase Pin1 is used in cancer to activate oncogenes and inactivate tumor suppressors.

Molecular Weight	281.8
Formula	C11H20ClNO3S
CAS No.	2451481-08-4
Appearance	Solid
Color	White to off-white
SMILES	O=C(N(CC(C)(C)C)C(CC1)CS1(=O)=O)CCl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vitro*	MDA-MB-468 cells show the most pronounced sensitivity to Sulfopin (1, 2.5 μM; 4-8 days). Sulfopin (2 μM, HEK293 cells; 48 hours) downregulates Myc transcription. Sulfopin (1, 2.5 μM; PATU-8988T cells; 4 days) shows a small but significant reduction in the number of synthesis (S)-phase cells and a corresponding increase of growth 1 (G1)-phase cells.
*In Vivo*	Sulfopin (40 mg/kg; p.o.; QD/BID for 7 days) regresses neuroblastoma in mice. Sulfopin (20-40 mg/kg; i.p.; daily for 27 days) inhibits pancreatic cancer progression in mice. Sulfopin (25-100 μM) blocks neuroblastoma in zebrafish.

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