Targefrin

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Catalog No.: PC0190

Size: 50 mg, 100mg, 250mg

Description

Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC₅₀ value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines.

Molecular Weight	1700.94
Formula	C85H116F3N19O15
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
*In Vitro*	Targefrin (0.025-10 μM; 20 min) effectively antagonizes EphA2 degradation in BxPC3 pancreatic cancer cells. Targefrin (2-10 μM; 24 h) significantly inhibits pancreatic cancer cell BxPC3 migration.
*In Vivo*	Targefrin (50 mg/kg; i.v.; for 5 days) suppresses tumor growth when conjugated with Paclitaxel.

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