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Targefrin

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Targefrin

Targefrin

Catalog No.: PC0190

Size: 50 mg, 100mg, 250mg

Description

Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC50 value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines.

Molecular Weight 1700.94
Formula C85H116F3N19O15
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
In Vitro Targefrin (0.025-10 μM; 20 min) effectively antagonizes EphA2 degradation in BxPC3 pancreatic cancer cells.
Targefrin (2-10 μM; 24 h) significantly inhibits pancreatic cancer cell BxPC3 migration.
In Vivo Targefrin (50 mg/kg; i.v.; for 5 days) suppresses tumor growth when conjugated with Paclitaxel.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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