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Toxicity Profiling
Alfa Cytology is a full-scale contract research organization (CRO) with extensive experience. Based on our comprehensive expertise in this area and advanced technology infrastructures, we provide exploratory and good laboratory practice-compliant toxicity services that enable clients to evaluate the safety and toxicity profiles of their new small molecule drug candidates.
Introduction to Toxicology
Toxicology is to predict the severity of harm to the body by studying the harmful effects of drugs on the body and their mechanism of action. Toxicology testing plays a crucial role in assessing the safety of a drug. By studying how drugs interact with biological systems, toxicology testing provides critical data for therapy development to make informed decisions about associated risks.
Fig. 1 The potential role of toxicology in drug discovery and development. (Nick J.P., 2015)
Toxicity caused by drugs is the main reason for drug withdrawal from the market, the most common of which are hepatotoxicity and cardiac toxicity. During drug development, potential drug candidates often fail due to unacceptable levels of toxicity. Therefore, predicting the potential toxicity of candidate compounds is critical to the successful development of drugs. Early drug toxicity testing can save time and cost, reducing the likelihood of preclinical or clinical stage failure.
Our Services
Toxicity profiling refers to the comprehensive evaluation of the potential adverse health effects and toxicity. Alfa Cytology offers a range of high-quality toxicology assessment services, including creating a "fingerprint" of toxicological information known as a toxicity profile. Our toxicity profiling service team consists of experienced and skillful scientists who work closely with each other to deliver value by achieving the seamless integration of programs. Our clients can fully trust our capabilities.
Toxicology Profiling
Alfa Cytology provides world-class safety assessment and toxicology services through comprehensive expertise and state-of-the-art infrastructures.
- General toxicology
- Genetic toxicology
- Local toxicity
- Tissue cross-reactivity
- Developmental and reproductive toxicology
- Immunogenicity and immunotoxicity
- Toxicokinetics
- Safety pharmacology
Infrastructure and Expertise
Alfa Cytology has advanced experimental equipment and a perfect experimental platform for toxicity testing, providing services in a modular and integrated manner during drug development according to our customer's requirements.
- Research equipment for pain and inflammation
- Qualitative and quantitative image analytics
- HPLC and LC-MS/MS instruments
- Hematology and biochemical analysis equipment
- Advanced vivarium with imaging instruments and animal activity meters
- Multiple histopathology software
Why Choose Us?
Customized solution
Highly-experienced expert team
Variety of preclinical models
Quick turnaround time
Worldwide service
Thanks for your interest in our toxicity profiling for pancreatic cancer (PC) drugs service, which is part of our integrated therapy development for PC. It takes specialized capabilities and extensive resources to develop therapies. Alfa Cytology is a solution provider with a deep appreciation of both the challenges and the potential of PC therapy. For more details on how we help our clients identify new ways to improve study design and anticipate development challenges, please feel free to contact us. We've got everything covered for your needs and look forward to working with you on your next project.
Reference
- Nick J. P, An introduction to systems toxicology, Toxicology Research, Volume 4, Issue 1, January 2015, Pages 9–22, https://doi.org/10.1039/c4tx00058g
