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Trigonelline chloride

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Trigonelline chloride

Trigonelline chloride

Catalog No.: PC0137

Size: 100 mg, 500 mg, 1 g, 5 g

Description

Trigonelline chloride, an alkaloid with potential antidiabetic activity, is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing pancreatic cancer cell apoptosis.

Molecular Weight 173.6
Formula C7H8ClNO2
CAS No. 6138-41-6
Appearance Solid
Color White to off-white
SMILES C[N+]1=CC(C(O)=O)=CC=C1.[Cl-]
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
In Vitro It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells.
In Vivo Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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