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Triphen diol

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Triphen diol

Triphen diol

Catalog No.: PC0085

Size: 50 mg, 100mg, 250mg.

Description

Triphen diol is a phenolic diol derivative with excellent anticancer activity against pancreatic cancer and cholangiocarcinoma and induces pancreatic cell apoptosis through both caspase-mediated and caspase-independent mechanisms.

Molecular Weight 348.39
Formula C22H20O4
CAS No. 1213777-80-0
SMILES OC1=CC=C2C(OC[C@H](C3=CC=C(O)C=C3)[C@@H]2C4=CC=C(OC)C=C4)=C1
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
In Vitro Triphen diol (0-10 μM, 48-120 h) can inhibit the proliferation of pancreatic cells and induce apoptosis, with an IC50 value of 8 μM for HPAC and PANC-1 cells and an IC50 value of 0.8 for MIAPaCa-2 cells μM.
In Vivo Triphen diol (50 mg/kg, oral gavage, daily, 15 days) can significantly inhibit tumor proliferation in male Balb/c nude mice transplanted with MIAPaCa2 cell line, and can be combined with gemcitabine to show better efficacy.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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