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YUM70

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YUM70

YUM70

Catalog No.: PC0042

Size: 1 mg, 5 mg,10 mg, 25 mg,50 mg, 100 mg, 200 mg, 500 mg

Description

YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM for inhibiting the ATPase activity of the full-length protein GRP78. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in pancreatic cancer xenograft models.

Molecular Weight 398.84
Formula C21H19ClN2O4
CAS No. 423145-35-1
Appearance Solid
Color White to off-white
SMILES CCCC(NC(C1=CC=C(OCO2)C2=C1)C3=CC(Cl)=C4C=CC=NC4=C3O)=O
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
In Vitro YUM70 shows selective cytotoxicity for MIA PaCa-2, PANC-1, BxPC-3 cells (IC50=2.8, 4.5, and 9.6 μM, respectively) over normal pancreatic tissue-derived HPNE cells (IC50>30 μM).
YUM70 (5 μM; 24 h) induces endoplasmic reticulum (ER) stress-mediated apoptosis of MIA PaCa-2cells.
In Vivo YUM70 (30 mg/kg; i.p. 5 days a week for 7 weeks) inhibits tumor growth in a MIA PaCa-2 xenograft model.
YUM70 (15 mg/kg; i.v.) exhibits t1/2 (1.40 h), CL (724.04 mL/h/kg), and Vss (1162.73 mL/kg) in mice.
YUM70 (30 mg/kg; p.o.) exhibits bioavailability (6.71%), t1/2 (2.74 h), and CL (9230.15 mL/h/kg) in mice.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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