Single Cell ICP-MS for Cancer Research
One breakthrough technique that has revolutionized the study of cancer at the single-cell level is inductively coupled plasma mass spectrometry (ICP-MS). At Alfa Cytology, we offer comprehensive services that leverage the power of single cell ICP-MS for cancer research.
Introduction to Single Cell ICP-MS
- Advancements in Cancer Research: Focus on Metallodrugs
Cancer research has made significant strides in recent years, leading to the development of novel therapies. One area of research that has garnered considerable attention is the study of metallodrugs, particularly platinum compounds. However, the efficacy of platinum compounds is often limited by the development of inherent or acquired platinum resistance, which remains a challenge to overcome.
- Role of Single Cell ICP-MS in Cancer Therapy
Single cell ICP-MS is a powerful analytical technique that allows for the precise and accurate quantification of metallodrugs at the single-cell level. This technology has revolutionized the field of cancer research by enabling the investigation of cellular substructures and their interactions with metallodrugs. Single cell ICP-MS provides valuable insights into the uptake, distribution, and concentration of metallodrugs within individual cancer cells and organelles, such as nuclei.
Fig.1 Workflow to prepare a single cell suspension from a solid tissue. (Álvarez-Fernández García, R., et al., 2022)
Our Services
At Alfa Cytology, we specialize in offering a comprehensive range of services utilizing single cell ICP-MS for cancer research. Our services include, but are not limited to:
Quantification of Metallodrugs in
Single Cells
We can accurately measure the concentration of metallodrugs, such as cisplatin, within individual cancer cells. By comparing the uptake of metallodrugs in cancer cells and resistant sublines, we can identify potential factors contributing to resistance and devise targeted interventions.
Investigation of Cellular
Substructures
By quantifying the concentration of metallodrugs within the nuclei of cancer cells, we gain insights into the subcellular localization and potential accumulation of these compounds. This information is invaluable for designing and optimizing drug delivery strategies that can enhance the efficacy of metallodrugs.
Evaluation of Novel
Metallodrugs
At Alfa Cytology, we are actively involved in the evaluation of novel metallodrugs developed for cancer treatment. By quantifying their uptake and distribution patterns, we can determine their potential as promising candidates for further development.
Our Advantages
Largest Toolbox
Strong Expertise
One-stop Solution
Short Turnaround
Single cell ICP-MS is a powerful tool in cancer research, enabling the precise quantification of metallodrugs at the single-cell level and the investigation of cellular substructures. At Alfa Cytology, we are dedicated to harnessing the potential of this technology to support researchers in navigating the complex landscape of single-cell analysis. If you are interested in our service, please contact us for more details.
Reference
- Álvarez-Fernández García, R., et al.; (2022). Capabilities of Single Cell ICP-MS for the Analysis of Cell Suspensions from Solid Tissues. Nanomaterials, 13(1), 12.
For research use only.
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