Spatial Omics Services for Cancer Research
Spatial omics is a pioneering methodology that integrates genomic analysis with spatial data to achieve a thorough understanding of cancer at the cellular level. At Alfa Cytology, we offer comprehensive spatial omics services, providing valuable insights into the spatial organization and heterogeneity of tumors.
Introduction to Spatial Omics
Spatial omics refers to the integration of multiomics data with spatial information, enabling the characterization of molecular profiles within their native tissue context. By leveraging multiplexed fluorescence, DNA, RNA, and isotope labeling techniques, spatial omics allows for the simultaneous detection of tens to thousands of cancer subclones or molecular biomarkers within their precise spatial locations. This information is crucial for unraveling the intricate cellular heterogeneity, deciphering the impact of the tumor microenvironment, and identifying potential therapeutic targets.
Fig.1 Spatial multiomics analysis of tissue samples to extract biological insights for clinical applications. (Zhang Y, et al., 2024)
Our Services
At Alfa Cytology, we offer a comprehensive range of spatial omics services tailored to meet the diverse needs of cancer researchers. Our advanced technologies and expertise enable us to provide high-quality data and actionable insights, empowering our clients to make breakthrough discoveries.
Our services include, but are not limited to:
Multiplexed Imaging for Spatial Profiling
We employ state-of-the-art multiplexed imaging technologies to visualize and quantify multiple biomarkers simultaneously within tissue samples. By using a combination of fluorescence, DNA, RNA, and isotope labeling, we can detect tens to thousands of cancer subclones or molecular biomarkers within their native spatial context.
Spatial Transcriptomics for Gene Expression
Spatial transcriptomics allows us to simultaneously analyze the gene expression profiles of thousands of cells while preserving their spatial information. By integrating histological images with transcriptomic data, we can identify cell types, map gene expression patterns, and unravel the heterogeneity within tumor tissues.
Spatial Proteomics for Protein Profiling
Our spatial proteomics services enable in-depth protein profiling within the context of tissue architecture. Using advanced imaging techniques coupled with antibody-based detection, we can analyze the spatial distribution of specific proteins and their abundance in different cellular compartments.
Data Integration and Analysis
Our bioinformatics experts employ advanced algorithms and computational tools to integrate spatial omics data with other omics datasets, enabling a systems-level understanding of tumor biology. We provide customized analysis pipelines and interactive visualization platforms to facilitate data exploration and hypothesis generation.
Our Advantages
Largest Toolbox
Strong Expertise
One-stop Solution
Short Turnaround
Spatial omics has emerged as a powerful tool in cancer research, enabling the investigation of cellular and molecular characteristics within their native spatial context. By collaborating with Alfa Cytology, researchers can unlock the complex biology of tumors, gain unprecedented insights into tumor heterogeneity, and pave the way for the development of personalized cancer diagnostics and therapeutics. If you are interested in our service, please contact us for more details.
Reference
- Zhang, Y., et al.; (2024). Spatial omics techniques and data analysis for cancer immunotherapy applications. Current Opinion in Biotechnology, 87, 103111.
For research use only.
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