Spontaneous Tumor Model Development Services
Alfa Cytology is committed to providing our clients with one-stop spontaneous tumor model development services, aiming to provide reliable, reproducible and translatable models that accurately reflect human disease, to accelerate the process of translating from the lab to therapy.
Overview of Spontaneous Tumor Models
The spontaneous tumor models are among the first used animal models for cancer research and for evaluation of chemopreventive agents, which mimics the natural occurrence and progression of animal tumors without the need for external carcinogens. The main feature of spontaneous tumor models is their ability to replicate the stochastic nature of tumorigenesis and progression influenced by genetic susceptibility and environmental factors.
Fig.1 Widely used methods for generation of transgenic mice. (Onaciu, A., et al., 2020)
Due to specific genetic backgrounds, different animal species have different susceptibility to spontaneous tumors. Spontaneous tumor models typically involve the use of genetically engineered mice (GEMs) or other animal models that naturally produce tumors due to specific genetic modifications. These models provide a reliable platform for studying complex interactions in the tumor microenvironment, genetic mutations, and the overall dynamics of tumor growth.
Our Services
Leveraging the well-established technology platform of the tumor microenvironment center, Alfa Cytology offers a wide range of spontaneous tumor models for specific types of cancers and can customize modeling solutions for specific project needs. We follow the latest research and industry standards to ensure that each model accurately reflects the biology of the respective human disease.
Spontaneous Tumor Models Available
Alfa Cytology has bred spontaneous tumor models for a variety of cancer types, some examples of which are listed below. Our service list is constantly being updated and improved, and you can contact us by email for more up-to-date and relevant information.
|
Type of Cancer |
Spontaneous Tumor Models Available |
| Breast Cancer |
MMTV-PyMT and BRCA1/2 knockout mice models. |
| Colorectal Cancer |
ApcMin/+ mice and genetically engineered models with mutations in the KRAS and TP53 genes. |
| Lung Cancer |
Spontaneous models with mutations in EGFR, KRAS, and TP53 genes, such as the LSL-KRASG12D and SPC-rtTA/TetO-EGFRL858R mice. |
| Pancreatic Cancer |
KPC (KRAS, TP53) mice models. |
| Prostate Cancer |
TRAMP (Transgenic Adenocarcinoma of the Mouse Prostate) models and PTEN knockout mice. |
| Ovarian Cancer |
MISIIR-TAg and BRCA1/2 knockout mice models. |
| Bladder Cancer |
Genetically engineered models with FGFR3, HRAS, and TP53 mutations (e.g., UPKII-SV40T mice). |
| Melanoma |
BRAF and NRAS mutant mice models. |
| Liver Cancer |
Hepatocellular carcinoma models with alterations in genes like c-MYC, β-catenin, and TP53 (e.g., Myc;Trp53 mice). |
| Gastric Cancer |
Models such as gp130F/F and mice with mutations in E-cadherin and KRAS. |
Applications of Spontaneous Tumor Models
Alfa Cytology offers spontaneous tumor models that can be applied to a wide range of research topics, providing a powerful platform for advancing cancer research.
Drug Preclinical Evaluation
Study the efficacy, pharmacokinetics and toxicity of potential therapeutic agents.
Biomarker Discovery
Identify and validate biomarkers for early cancer detection, prognosis and treatment response.
Tumor Mechanism Research
Dissect the mechanisms of tumorigenesis, progression and metastasis and identify potential therapeutic targets.
Immunotherapy Research
To study the interaction between the immune system and tumors and to test the efficacy of immunotherapy.
With extensive experience in various cancer models and expertise in a wide range of cancer modeling, Alfa Cytology is the ideal partner to support your oncology therapeutic research. We provide customers with stock model products, model customization, and joint R&D services to provide you with the best tumor models and look forward to meeting your precise needs. Please let us know your project requirements and we will provide you with a comprehensive service from solution to report. For further inquiries and custom model development, please feel free to contact us.
Reference
- Onaciu, A., et al.; (2020). Spontaneous and induced animal models for cancer research. Diagnostics, 10(9), 660.
For research use only.
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