Antibody Characterization Service
Antibody characterization plays a crucial role in research and the development of biopharmaceuticals. The final product of therapeutic antibodies, produced using current technologies, exhibits heterogeneities due to various modifications occurring at different stages of production. Thorough characterization is therefore essential for ensuring reproducible and safe production of therapeutic antibodies. At Alfa Cytology, we offer a range of techniques to comprehensively characterize antibodies.
Fig.1 Schematic drawing of intact IgG1 and IdeS-cleaved IgG1 fragments. (Zhao, P., et al., 2021)
Importance of Antibody Characterization
Antibody characterization is a critical component in the preclinical development of therapeutic antibodies, especially in the context of bladder cancer research. Understanding the specific attributes of an antibody allows for the optimization of its therapeutic potential, ensuring that it is both effective and safe for subsequent clinical applications.
Enhancing Efficacy
Comprehensive characterization identifies antibodies with high affinity and specificity to bladder cancer antigens, ensuring effective targeting and minimal off-target effects.
Ensuring Safety
Detailed analysis helps predict and reduce immunogenicity, preventing adverse immune reactions and ensuring the safety of antibody candidates.
Quality Control
Rigorous characterization ensures structural integrity, functional activity, and purity of antibodies, providing consistent quality for reliable preclinical studies.
Supporting Targeted Therapy
Characterizing antibodies specific to bladder cancer biomarkers aids in developing targeted therapeutic strategies, enhancing the relevance of preclinical findings.
Our Services
Alfa Cytology offers comprehensive antibody-drug characterization services, encompassing the detection, characterization, and quantification of impurities. Additionally, we provide crucial insights into structural variants and modifications of the final product, as well as affinity, stability, immunogenicity, and safety parameters.
Antibody Structure and Function Characterizations
Accurate characterization of antibody structure and modifications is crucial for ensuring functionality and stability. In our bladder cancer research services, we utilize advanced techniques to thoroughly analyze the structure and any modifications of antibodies, optimizing their performance.
| Service Category |
Service |
| Antibody Primary Structure Analysis |
Molecular Weight Determination of Intact Antibody Drugs |
| Antibody N-Terminal Sequencing |
| Antibody C-Terminal Sequencing |
| Antibody Amino Acid Analysis |
| Antibody Advanced Structure Analysis |
Secondary Structure |
| Tertiary Structure |
| Antibody Modification Analysis |
Glycosylation Analysis |
| Phosphorylation Analysis |
| Deamidation and Oxidation analysis |
| Disulfide Bridges & Free Sulfhydryl Groups Analysis |
| C-terminal Lysine Variants Determination |
| Functionality Analysis |
Mass Spectrometry-based Epitope Mapping |
| Surface Plasmon Resonance (SPR) Service |
Quality Control
Quality control is a core component in ensuring the consistency and reliability of antibody products during development. We strictly adhere to industry standards and implement comprehensive quality control measures to ensure that every antibody sample meets the highest quality standards.
| Service Category |
Service |
| Impurity Analysis |
Purity Analysis |
| Charge Heterogeneity Analysis |
| Analysis of Residual Protein A in Host Cells |
| Analysis of Foreign DNA Residues |
Contact Us
Enhance your bladder cancer research with our comprehensive antibody characterization services. Contact us today to discuss your project requirements and discover how we can support your success.
Reference
- Zhao, P., Gunawardena, H. P., and et al. Microdroplet Ultrafast Reactions Speed Antibody Characterization Analytical chemistry, 2021, 93(8), 3997–4005.
For research use only. Not intended for any clinical use.
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