Cell Line-Derived Xenograft Model Development Service

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The cell line-derived xenograft tumor (CDX) model is a tumor model constructed by transplanting an in vitro cultured xenogeneic (human-derived) tumor cell line into an immunodeficient mouse. Alfa Cytology provides customized CDX models for bladder cancer research.

Cell Line-Derived Xenograft (CDX) Models

CDX models involve the transplantation of bladder cancer cell lines into immunodeficient animals, typically mice. These cell lines are derived from human and possess specific genetic and molecular characteristics. CDX models offer several advantages in preclinical research, including ease of use, reproducibility, and scalability. By utilizing CDX models, we can investigate tumor biology, evaluate therapeutic efficacy, and elucidate underlying mechanisms of bladder cancer progression.

Cell Line-Derived Xenograft (CDX) Model

Tumor Cells

Immunodeficient mouse

Transplant

They offer several advantages that enhance preclinical drug efficacy testing and analysis.

Accessibility and Reproducibility
Experimental Flexibility and Efficiency

Cost-Effectiveness and Scalability
Mechanistic Insights

Our Services

Alfa Cytology, a leading preclinical Contract Research Organization (CRO), offers a variety of customization services for cell line-derived xenograft mouse models to develop novel bladder cancer therapies.

Cell Line-Derived Xenograft Model Development Service

Cell Line Selection	Animal Selection
Through rigorous screening and characterization, we ensure the authenticity, stability and genetic fidelity of the selected cell lines. The cell lines mainly used to construct CDX models were 5637, 5637-luc, UMUC3, 786-o-luc, RT4, SW-780.	Taking into account factors such as implantation efficiency, tumor growth kinetics, and compatibility with the selected cell line, we provide you with the most appropriate strain, such as nude mice, NOD SCID mice, or M-NSG mice, to ensure optimal tumor engraftment and growth.
Implantation Techniques	Tumor Monitoring
We offer accurate and reproducible tumor cell implantation. Whether via subcutaneous or in situ (bladder), we carefully implant bladder cancer cells into mice to optimize tumor growth.	Our regular monitoring of tumor growth using non-invasive imaging techniques such as bioluminescence or ultrasound allows for longitudinal assessment and accurate evaluation of therapeutic efficacy.

Our Services Will Help You Achieve the Goals as Follows:

CDX models are increasingly being used to enable the following types of preclinical research for bladder cancer:

Anti-cancer Drug Screening
PK/PD Studies for Bladder Cancer Drugs
Biomarker and New Drug Target Development

Immuno-Oncology Research
Exploring Tumor Biology and Metastasis
Evaluation of the Efficacy of Combination Therapy

Contact Us

In the quest for improved diagnostics and treatments for bladder cancer, the development of reliable and clinically relevant preclinical models is of paramount importance. Through meticulous cell line selection, precise implantation techniques, in vivo pharmacology studies, and rigorous data analysis, Alfa Cytology empowers our clients to make significant strides in understanding bladder cancer biology and identifying promising therapeutic candidates. If you have any needs, please contact us.

Reference

Cai E. Y., Garcia J., and et al. A bladder cancer patient-derived xenograft displays aggressive growth dynamics in vivo and in organoid culture. Sci Rep. 2021, 25, 11(1): 4609.

For research use only. Not intended for any clinical use.

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* Please note that we are not a pharmacy or clinic, so we do not offer diagnostic and treatment services for patients.

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