Exosome Tracer Service for Bladder Cancer
Exosomes are small extracellular vesicles that are released by various cell types, including but not limited to, immune cells, stem cells, and cancer cells with a diameter ranging from 30 to 150 nanometers. Exosomes have gained significant attention as potential sources of biomarkers for bladder cancer. Alfa Cytology offers comprehensive exosome-based analysis services for you.
Exosome in Bladder Cancer
Exosomes play important roles in intercellular communication by transferring various biomolecules, such as proteins, nucleic acids (including RNA and DNA), lipids, and metabolites, between cells. Exosomes and their contents can regulate cell proliferation, cell cycle, invasion and migration, metastasis, angiogenesis and cisplatin chemoresistance in bladder cancer.
Fig.1 The signaling pathways involved in exosomes regulating bladder cancer progression. (Yang, Y., et al. 2023)
To further advance the investigation and application of exosomes in bladder cancer, the development of imaging and visualization studies to track exosomes is necessary. Tracing the movement and interactions of exosomes can help researchers understand their roles in tumor progression and identify potential diagnostic or therapeutic targets.
Our Services
In vivo tracing of isolated exosomes is helpful for further studies on the functions and applications of exosomes. At Alfa Cytology, we provide exosome tracking service enabling real-time monitoring and visualization of the dynamic distribution and functionality of exosomes within living organisms, supporting customers in acquiring profound insights into the intricate mechanisms of exosomes in biological processes.
| Exosome Tracer Services |
| Visualizing Methods |
Reporters |
Advantages |
Applications |
| Bioluminescence imaging (BLI) |
Gaussia-luciferase (Gluc) |
Excellent signal-to-noise ratio (SNR)
High sensitivity
No need for excitation source |
In vivo and ex vivo |
| Magnetic resonance imaging (MRI) |
SPIONs, USPIO |
Deep penetration
High-quality 3D imaging of tissues with anatomical details |
In vivo |
| Computed tomography (CT) |
Gold Nanoparticles (GNPs) |
High spatial and temporal resolution |
In vivo |
| Nuclear imaging |
Radioisotopes |
Noninvasive imaging |
In vivo |
| Photoacoustic imaging |
Graphene quantum dot nanozyme |
Deep tissue penetration
High spatial resolution |
In vivo and ex vivo |
| GNPs |
| Fluorescence imaging |
Organic dyes |
High sensitivity
High Selectivity and specificity |
In vitro |
| GNPs |
In vivo and ex vivo |
| Aggregation-induced Emission Luminogens (AIEgens) |
In vivo and ex vivo |
| Genetically encoded fluorescent proteins |
In vivo and ex vivo |
| Immunofluorescent reporters |
In vitro |
| Quantum dots (Qdots) |
In vivo and ex vivo |
Our Services Will Help You Achieve the Following Goals:
- Visualization of exosome biogenesis in bladder cancer.
- Tracking exosome trafficking of bladder cancer cells.
- Characterizing exosome interactions with recipient cells.
- Studying exosome-mediated intercellular communication between bladder cancer cells and stromal cells.
- Investigating exosome localization in tissues and organs for bladder cancer metastatic sites.
- Assessing exosome-based therapies for bladder cancer.
Workflow of Our Services
01
Exosome extraction and purification
02
Exosome concentration determination
03
Exosome fluorescent labeling
04
Fluorescence exosome purification
Contact Us
If you are interested in our exosome tracer services for bladder cancer research or have any inquiries, please feel free to contact us. Our dedicated team is ready to provide you with further information and discuss how we can support your research goals. Together, we can accelerate the development of early diagnosis and therapeutic strategies for bladder cancer.
Reference
- Yang Y., Miao L., and et al. Exosome, the glass slipper for Cinderella of cancer—bladder cancer? J Nanobiotechnol. 2023, 21, 368.
For research use only. Not intended for any clinical use.
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