In Vitro ADME Services for Bladder Cancer Therapy
ADME stands for 'absorption, distribution, metabolism and excretion' and understanding the ADME properties of compounds is essential for drug development. Through our in vitro ADME service, we can provide accurate and valuable information that is important in the early stages of drug discovery and development for bladder cancer.
Overview of In Vitro ADME
Bladder cancer is a complex and challenging disease that affects a significant number of people worldwide. Developing effective drugs to treat bladder cancer requires a comprehensive understanding of how these drugs are metabolized and eliminated from the body.
Fig 1. The in vitro ADME-Tox culture system. (Ishida S. 2018)
In Vitro ADME Including:
Absorption
By studying factors such as drug solubility, permeability, and transporters, researchers can make informed decisions about the formulation and administration of bladder cancer drugs.
Distribution
We can assess a drug's ability to reach bladder tumors and other relevant tissues by studying factors such as drug binding to plasma proteins and tissue penetration.
Metabolism
In vitro ADME studies help identify the enzymes responsible for drug metabolism and assess the potential for drug-drug interactions to allow us optimize the structure of drugs and minimize the risk of adverse reactions.
Excretion
Effective excretion of drugs and their metabolites is critical to avoid toxicity. In vitro ADME services allow us to study drug excretion mechanisms such as renal clearance and bladder excretion rates.
Our Services
Alfa Cytology provides a variety of in vitro ADME services, including high-throughput ADME screening, in vitro binding, in vitro metabolism, and in vitro permeability for bladder cancer drug development. Our team of experienced scientists employs state-of-the-art techniques to generate reliable and informative data for drug discovery and development.
Our services include but are not limited to:
Physicochemical Characterization
- Aqueous Solubility Studies
- Lipophilicity
- pKa
- Stability
Permeability and Absorption
- Dermal Absorption
- Parallel Artificial Membrane Permeability Assay (PAMPA)
- Caco-2 Permeability
- MDCK Permeability
- Transporter Substrate Identification
Drug Distribution
- Plasma Protein Binding
- Blood Plasma Partitioning
- Brain Tissue Binding
- Microsomal Binding
In Vitro Metabolism
- Matrix Stability Assays
- Metabolic Stability Assays
- CYP Inhibition, CYP TDI, kobs
- CYP Induction P-gp
- BCRP Inhibition & Substrate Identification
Our Advantages
Professional and well-trained core technical team.
Advanced experimental equipment.
Strict quality control system.
Empowering success through cooperation.
Contact Us
If you are involved in bladder cancer drug development and require professional in vitro ADME services, Alfa Cytology is here to assist you. Our team of dedicated scientists and cutting-edge facilities are ready to support your research needs. To learn more about our services or to discuss a potential collaboration, please contact us.
Reference
- Ishida S. Organs-on-a-chip: Current applications and consideration points for in vitro ADME-Tox studies. Drug Metabolism and Pharmacokinetics. 2018, 33, 1, 49-54.
For research use only. Not intended for any clinical use.
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