Patient-derived xenografts (PDX) indeed refer to patient-derived tumor tissue that is transplanted into immunodeficient animals, typically mice, for preclinical research purposes. Alfa Cytology provides customized PDX models for bladder cancer research.

PDX Models for Bladder Cancer

PDX models have been recognized as advanced preclinical oncology drug development models. They are widely used in bladder cancer research and therapeutic development due to their ability to recapitulate the heterogeneity and diversity of bladder cancers more accurately. PDX models can also be propagated by sequential transplantation, thus allowing tumor cells to be expanded and maintained for multiple generations.

They offer several advantages that enhance preclinical drug efficacy testing and analysis.

Our Services

Alfa Cytology, a leading preclinical Contract Research Organization (CRO), offers a variety of customization services for PDX mouse models to develop novel bladder cancer therapies. Our expert staff can provide you with comprehensive experimental procedures, health reports and relevant experimental data.

Workflow of Our Service

• Sourcing of Samples

We help find and coordinate access to tumor samples and established PDX models. We recovered these models from cryopreservation, implanted and successively retransmitted them to expand and build the models, and then used them to implant groups of mice for therapeutic studies.

• PDX Implantation

Our skilled technicians implant primary patient samples or existing PDX models into immunocompromised mice via a variety of heterotopic and orthotopic methods.

• Serial Repassaging of PDX Models

Appropriately sized implanted tumors are collected after tumorectomy. This tumor tissue is used for serial repassaging into mice to establish the model and for further expansion and secondary implantation/repassaging to produce a study cohort all bearing the same tumor.

• Tumor Growth Monitoring and Measuring, Record-Keeping, Data Entry, Tumor Growth Charts and Passage Charts

Our technicians monitor the mouse models by visual health assessment, weight monitoring and caliper measurements of tumors along with noninvasive monitoring when requested or necessary.

Our Services Will Help You Achieve the Goals as Follows:

PDX models are increasingly being used to enable the following types of preclinical research for bladder cancer:

Contact Us

Alfa Cytology is dedicated to advancing bladder cancer research through our specialized preclinical CRO services. Our team of highly skilled scientists and experts are ready to collaborate with researchers to accelerate their projects and facilitate the discovery of early diagnosis and treatment solutions for bladder cancer. To learn more about our PDX model development services or to discuss your specific research needs, please contact us.

• Carcinogen-Induced Model Development Service
• Cell Line-Derived Xenograft Model Development Service
• Genetically Engineered Model Development Service
• Preconditioned Animal Model Development Service
• Tumor Metastatic Model Development Service