Bacteria-based Delivery System Development
Alfa Cytology specializes in the development and optimization of microchip-based delivery systems for brain tumors to enhance targeted drug delivery, overcome the blood-brain barrier, and improve therapeutic efficacy while minimizing systemic toxicity.
Introduction to Bacteria-Based Delivery Systems for Brain Tumors
Bacteria, a class of prokaryotic organisms with nucleoplasm without a nuclear membrane envelope, have an unexpected role in brain tumor treatment. Certain anaerobic bacteria readily grow in hypoxic tumor regions, and with increased metabolic byproducts in the tumor region, these anaerobes can easily survive to destroy the tumor tissue. Certain bacteria can naturally colonize tumor sites, known as tumor targeting. Using this ability to design brain tumor drug delivery systems with drug-targeted transport has promising applications.
Fig.1 The Role of Bacteria in Central Nervous System Tumors. (Zhang R., et al., 2024)
Bacteria can penetrate the BBB through various mechanisms, including paracellular transport, intracellular uptake, and the exploitation of receptor-mediated endocytosis. For instance, Salmonella typhimurium has been engineered to enhance its ability to target hypoxic regions within tumors, thereby increasing therapeutic efficacy while minimizing systemic toxicity. This selectivity is pivotal in addressing the immunosuppressive tumor microenvironment that characterizes many CNS tumors.
Our Services
Many bacteria have been found to have the ability to target tumor regions. Based on this feature, Alfa Cytology is developing their potential as (metastatic) brain tumor drug carriers. By combining bacteria with drugs that have different excellent properties, we can overcome the shortcomings of conventional drugs such as low bioavailability, weak targeting performance, and poor tissue penetration.
Construction of Bacterial/ Nanomaterial Complexes
The anaerobic targeting properties of some anaerobic bacteria allow them to actively target and colonize the tumor microenvironment in the absence of oxygen. Therefore, we combined different nanomaterials with bacteria to form bacteria/nanomaterial complexes, which enhanced the targeting effect of the complexes on tumors.
- Bacteria/nanomaterials complex construction by chemical bonding
- Construction of bacteria/nanomaterial complexes using electrostatic interactions
- Construction of bacterial/nanomaterial complexes using specific biological recognition
Preclinical Testing and Validation
Our comprehensive preclinical services include in vitro and in vivo studies to validate the efficacy and safety of our bacteria-based delivery systems. We provide detailed reporting and analysis, ensuring that our clients receive robust data to support their research and development efforts.
- In Vitro Model
- In Vivo Model
- Efficacy Evaluation
- ADME
- Safety Assessment
Contact Us
For inquiries related to our bacteria-based delivery system development services, please contact us at Alfa Cytology. We are committed to advancing innovative solutions for the treatment of brain tumors and welcome collaboration with researchers and industry partners.
Reference
- Zhang R, et al. (2024) The Role of Bacteria in Central Nervous System Tumors: Opportunities and Challenges. Microorganisms. 2024, 12(6):1053.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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