Brain Tumor Microenvironment Analysis
Our brain tumor microenvironment analysis is committed to helping our clients investigate the underlying mechanisms of brain tumors and promote the development of new therapeutics. With professional knowledge and cutting-edge technology, Alfa Cytology provides advanced tumor microenvironment (TME) analysis services including characterization of brain tumor microenvironment, phenotyping of infiltration immune cells and tumor metabolic microenvironment assessment.
Introduction to Brain Tumor Microenvironment
The tumor microenvironment (TME) comprises complex cells and surrounding components including immune cells, lymphocytes, blood vessels, signaling molecules, etc. The tumor can shape its microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing immune tolerance, whereas the immune cells can in turn impact the growth and metastasis of tumor cells. Understanding the interactions within TME is crucial for unraveling the molecular mechanisms of brain tumors and advancing novel therapeutic strategies.
Fig.1 Tumor microenvironment and associated immune cell metabolism. (Bader JE., et al., 2020)
Targeting Tumor Microenvironment for Cancer Therapy
Since the tumor microenvironment has played a crucial role in tumor progression and regulates the efficacy of tumor therapeutics, researchers have concentrated on developing drugs that target TME. These strategies mainly target tumor-associated macrophages (TAMs), T cells, dendritic cells, tumor angiogenesis, the extracellular matrix and cancer-associated fibroblasts (CAFs). Furthermore, scientists have discovered that a comprehensive systems-level approach toward TME yields better results than targeting individual cell types.
| Targets |
Drug types |
| TAMs |
CSF1R inhibitors, CCL2/CCR2 inhibitors, CD47/SIRPα complex antagonists, PI3Kγ inhibitors, etc. |
| T cells |
PD-1/PD-L1 inhibitors, LAG3 Inhibitors, TIM3 Inhibitors and TIGIT Inhibitors. |
| Tumor angiogenesis |
VEGFA inhibitors |
Our Services
At Alfa Cytology, we are committed to providing well-established tumor microenvironment analysis services tailored to brain tumor research and drug development. The services we provide include but are not limited to the following contents.
Tumor Microenvironment Spatial Imaging
- Analysis of brain tumor spatial biology by multiple spatial tissue analysis (MSTA) and high-throughput immunofluorescence imaging.
Immune Profiling
- Quantification of infiltrating innate and adaptive immune cells (T cells, B cells, Treg cells, NK cells, macrophages, monocytes and neutrophils) by flow cytometry and single-cell sequencing.
- Characterization of various cell types within TME including B cell assays, T cell assays, dendritic cell assays, macrophage cell assays, fibroblast assays, neutrophil assays and NK cell assays.
Metabolic Analysis
- Sampling and quantification of multiple immunomodulators and oncometabolites by microdialysis.
- Detection of pH in the tumor microenvironment by PET radiotracer.
- Analysis of hypoxia by photoacoustic microscopy.
Our Solutions Will Help You Achieve the Following Goals
- Investigate the dynamic crosstalk between tumor cells and immune cells within the brain tumor microenvironment.
- Discover novel brain tumor biomarkers and potential drug targets.
- Accelerate the development of novel therapeutic agents and strategies for brain tumors.
Why Choose Us?
Customized
Solutions
In-depth
Analysis
Strong
Expertise
Short
Turnaround
At Alfa Cytology, we offer comprehensive brain tumor microenvironment analysis services to support researchers and pharmaceutical companies for brain tumor pathological research and drug development. If you have any inquiries or would like to learn more about our TME analysis services for brain tumors, please don't hesitate to contact us.
Reference
- Bader JE.; et al. (2020). Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy[J]. Molecular cell. 78(6): 1019–1033.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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