Single Cell Sequencing for Brain Tumors
Single-cell sequencing provides a powerful tool for researchers to delve into the genomic, epigenomic, transcriptomic and proteomic characteristics of brain tumor tissue at a single-cell level. Alfa Cytology offers advanced single-cell sequencing technology to provide profound insights into the pathogenesis of brain tumors.
Single Cell Sequencing in Brain Tumors
Single-cell sequencing refers to the analysis of genomics, epigenomics, transcriptomics, metabolomics and proteomics at single-cell resolution. With remarkable progress in single-cell isolation, next-generation sequencing, cDNA library preparation and analytical algorithms, single-cell sequencing has been widely used to decompose the heterogeneity of brain tumors both genomically and transcriptionally. Moreover, this innovative technology is also extensively employed for the analysis of rare cell populations associated with brain tumor initiation, progression and metastasis, including circulating tumor cells (CTCs) and cancer stem cells (CSCs).
Fig.1 Questions in cancer biology addressed by emerging directions with scRNA-seq. (Suvà ML., & Tirosh I, 2019)
Our Services
Exploring the intricate interactions among different cell types in brain tumors is of great importance. Single-cell sequencing emerges as a vital tool for uncovering mutations and structural variants present in the genomes of brain tumor cells. Alfa Cytology presents cutting-edge single-cell sequencing technology to elucidate the intricate architecture of brain tumors and offer fresh perspectives on their pathogenesis, aiming to advance the development of innovative therapeutics tailored to brain tumors.
Single-Cell
Genomics Services
Genomic variation analysis, which includes single-cell whole genome sequencing services and single-cell whole exome sequencing services, is provided to delve into the heterogeneity of brain tumors.
Single-Cell
Epigenomics Services
Specializing in single-cell ATAC sequencing and single-cell whole genome bisulfite sequencing, we can analyze DNA methylation, histone modification and chromatin structure at single-cell resolution.
Single-Cell
Transcriptomics Services
Single-cell RNA sequencing is employed to identify cell populations, decipher the functional states of tumor cells and uncover the intricate networks of gene regulation during brain tumor development.
Single-Cell
Metabolomics Services
Single-cell metabolomics services are offered for analyzing a diversity of metabolites at the single-cell level, aiding in the exploration of the metabolic heterogeneity present in brain tumors.
Single-Cell
Proteomics Services
The single-cell proteomics services provided empower the analysis of protein composition within individual cells, facilitating the discovery of brain tumor biomarkers and potential therapeutic targets.
Particularly, single nucleus RNA sequencing (snRNA-seq) is recognized for its ability to offer detailed insights into neurons, serving as a powerful tool in unraveling the cellular and molecular landscape of brain tumors. Alfa Cytology provides cutting-edge single nucleus RNA sequencing for brain tumors to examine the gene expression profiles of individual cell nuclei throughout the stages of brain tumor initiation, progression and metastasis.
Workflow of Single-cell Sequencing
Why Choose Us?
Customized
Solutions
In-depth
Analysis
Strong
Expertise
Short
Turnaround
Alfa Cytology excels at various single-cell sequencing technologies and provides well-established services to enhance your brain tumor research. Leveraging our expertise in brain tumor research and single-cell sequencing, we can assist you in exploring the diverse cellular states that drive brain tumor progression. Please don't hesitate to contact our staff to learn how we can support your brain tumor research.
Reference
- Suvà ML., & Tirosh I. (2019). Single-cell RNA sequencing in cancer: lessons learned and emerging challenges[J]. Molecular cell. 75(1), 7–12.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
Related Services
