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CSPG4,NG2 Polyclonal Antibody

CSPG4,NG2 Polyclonal Antibody

CAT#: OLD-D001

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Overview Specification

Target	CSPG4
Cell Type	Oligodendrocytes
Host	Rabbit
Isotype	IgG
Applications	WB, IHC, FC, ELISA
Reactivity	Human, Mouse, Rat
Conjugate	Unconjugated
Keywords	Oligodendrocytes; Rabbit; IgG; WB, IHC, FC, ELISA

Product Information	It targets CSPG4, NG2 in WB, IHC, FC, ELISA applications and shows reactivity with human, mouse, rat samples.
Background Information	CSPG4, also named as HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16 and NG2, is a proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. CSPG4 may inhibit neurite outgrowth and growth cone collapse during axon regeneration. It is cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. CSPG4 may regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. It modulates the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. CSPG4 functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. It promotes retraction fiber formation and cell polarization through Rho GTPase activation and stimulates alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. CSPG4 activates FAK and ERK1/ERK2 signaling cascades. The antibody is specific to CSPG4.
Full Name	Chondroitin sulfate proteoglycan 4
Synonyms	CSPG4, CSPG4,NG2, HMW MAA, MCSP, MCSPG, MEL CSPG, MSK16, Neuron-glia 2, NG2
Tested Reactivity	Human, mouse, rat
Cited Reactivity	Human, mouse, rat
Class	Polyclonal
Type	Antibody
Immunogen	Peptide
Calculated Molecular Weight	251 kDa
Observed Molecular Weight	240-250 kDa, 450kDa
Gene ID	1464
GenBank Accession Number	NM_001897
Gene Symbol	CSPG4
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	A375 cells

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