CXCR4 Monoclonal Antibody

CAT#: NSC-P004

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Overview Specification

Target	CXCR4
Cell Type	NSCs
Host	Mouse
Isotype	IgM
Applications	WB, IHC, IF, FC, CoIP, ELISA
Reactivity	Human, mouse
Conjugate	Unconjugated
Keywords	NSCs; Mouse; IgM; WB, IHC, IF, FC, CoIP, ELISA

Product Information	It targets CXCR4 in WB, IHC, IF, FC, CoIP, ELISA applications and shows reactivity with human, mouse samples.
Background Information	C-X-C chemokine receptor type 4 (CXCR4) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021). CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609). CXCR4 has a calculated molecular weight of 40 kDa. In addition to the predicted species of 45-47 kDa for glycosylated CXCR4 monomers, due to ubiquitination, dimeration, and different degrees of glycosylation, additional species can also exist and have been reported in some researches, including 67 kDa (PMID: 23917520), 55, 67, 87 kDa (PMID: 20028517), 80 kDa (PMID: 10506573), 47, 50, 62, and 98 kDa (PMID: 16204649).
Synonyms	CD184, CXC R4, CXCR 4, CXCR4, CXCR4B, D2S201E, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, LESTR, SDF 1 receptor, WHIM
Full Name	Chemokine (C-X-C motif) receptor 4
Tested Reactivity	Human, mouse
Cited Reactivity	Human, mouse
Class	Monoclonal
Type	Antibody
Immunogen	CXCR4 fusion protein
Calculated Molecular Weight	352 aa, 40 kDa
Observed Molecular Weight	60~70 kDa
Gene ID	7852
GenBank Accession Number	BC020968
Gene Symbol	CXCR4
Form	Liquid
Purification Method	Caprylic acid/ammonium sulfate precipitation
Storage Buffer	PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	HeLa cells, K-562 cells, Daudi cells, Ramos cells, Jurkat cells, U-937 cells, THP-1 cells
Positive IHC Detected	Human tonsillitis tissue, mouse brain tissue, human prostate cancer tissue, human breast cancer tissue, mouse spleen tissue
Positive FC Detected	Jurkat cells

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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