DARPP32/PPP1R1B Polyclonal Antibody

CAT#: NEM-K002

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Overview Specification

Target	DARPP32
Cell Type	GABAergic neurons
Host	Rabbit
Isotype	IgG
Applications	WB, IHC, IF, ELISA
Reactivity	Human, mouse, rat
Conjugate	Unconjugated
Keywords	GABAergic neurons; Rabbit; IgG; WB, IHC, IF, ELISA

Product Information	It targets DARPP32/PPP1R1B in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
Background Information	Dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP32) , also known as protein phosphatase 1 regulatory subunit 1B (PPP1R1B), is a substrate of cAMP-dependent protein kinase (PKA) enriched in dopamine-innervated brain areas. Overexpression of DARPP32 has been shown to block gastric tumor cell apoptosis (PMID: 21741919). DARPP32 also drives lung tumor growth through a similar ERBB3-mediated resistance mechanism (PMID: 34675407). The molecular weight of DARPP32 is about 32 kDa.
Synonyms	DARPP 32, DARPP32, PPP1R1B
Full Name	Protein phosphatase 1, regulatory (inhibitor) subunit 1B
Tested Reactivity	Human, mouse, rat
Type	Antibody
Class	Polyclonal
Immunogen	DARPP32/PPP1R1B fusion protein
Calculated Molecular Weight	23 kDa
Observed Molecular Weight	32 kDa
GenBank Accession Number	BC001519
Gene ID	84152
Gene Symbol	PPP1R1B
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	Mouse brain tissue, HeLa cells, HEK-293 cells, human brain tissue, rat brain tissue
Positive IHC Detected	Mouse brain tissue, rat brain tissue
Positive IF Detected	Mouse brain tissue

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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