Meet Alfa Cytology at the Cancer R&D 2024, Nov 18-20, 2024. We look forward to connecting with you and providing expert solutions for your cancer drug development projects.

EOMES/TBR2 Polyclonal Antibody

EOMES/TBR2 Polyclonal Antibody

CAT#: NSC-P005

Inquiry

Overview Specification

Target	EOMES/TBR2
Cell Type	Intermediate progenitors
Host	Rabbit
Isotype	IgG
Applications	WB,ELISA
Reactivity	Human, mouse, rat
Conjugate	Unconjugated
Keywords	Intermediate progenitors; Rabbit; IgG; WB,ELISA

Product Information	It targets EOMES/TBR2 in WB, ELISA applications and shows reactivity with Human, Mouse, rat samples.
Background Information	EOMES/TRB2 (also named Eomesodermin/Tbr2) encode T-box transcription factor expressed highly in the intermediate progenitor stage of the developing neuron. During migration of the neurons, radial glia divide and migrate towards the surface of the cerebral cortex, there are three stages of cellular development: radial glia, intermediate progenitors, and postmitotic projection neurons. Radial glia express Pax6, while intermediate progenitor cells express Eomesodermin/Tbr2, and postmitotic projection neurons express Tbr1 (PMID:15634788; PMID:16320258). This process also called neurogenesis, and demonstrated that Eomesodermin/Tbr2 has been implicated in neurodevelopment. According to the mouse model, several articles showed that EOMES/TRB2 KO mice having proliferating cells decreased and having smaller upper cortical layers and a smaller sub ventricular zone in the brain (PMID:18940588). What's more, Eomesodermin/Tbr2 has also been found participating in immune response (PMID:20713880).
Synonyms	EOMES, Eomesodermin homolog, T box brain protein 2, T brain 2, TBR 2, TBR2
Full Name	Eomesodermin homolog (Xenopus laevis)
Tested Reactivity	Human, mouse, rat
Class	Polyclonal
Type	Antibody
Immunogen	EOMES/TBR2 fusion protein
Calculated Molecular Weight	73 aa
Observed Molecular Weight	70-72 kDa
Gene ID	8320
GenBank Accession Number	NM_001278182
Gene Symbol	EOMES
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	Mouse brain tissue

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Online Inquiry

Alfa Cytology provides its clients with one-stop solutions to accelerate therapeutic discovery and development of brain tumors.

By Disease

Craniopharyngioma

Schwannoma (neuroma)

Pituitary Tumors

Choroid Plexus Tumors

By Molecule Type

Small Molecule Drug

Therapeutic Antibody

Immune Cell Therapy

Oncolytic Virotherapy

Vaccine Development

Contact Us

Copyright © 2024 Alfa Cytology. All rights reserved.