EZH2 Polyclonal Antibody

CAT#: OLD-D003

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Overview Specification

Target	EZH2
Cell Type	Oligodendrocytes
Host	Rabbit
Isotype	IgG
Applications	WB, RIP, IP, IF, FC, CoIP, ChIP, ELISA
Reactivity	Human, Mouse, Rat, Pig
Conjugate	Unconjugated
Keywords	Oligodendrocytes; Rabbit; IgG; WB, RIP, IP, IF, FC, CoIP, ChIP, ELISA

Product Information	The immunogen of EZH2 Fusion Protein expressed in E. coli.
Background Information	EZH2 (enhancer of zeste homologue 2, also known as KMT6) is a member of Polycomb group (PcG) family and encodes a histone methyl transferase that has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing. EZH2 is important for cell proliferation and inhibition of cell differentiation, and is implicated in cancer progression. Overexpression of EZH2 is a marker of advanced and metastatic disease in many solid tumors, including prostate and breast cancer. This antibody detected EZH2 protein as a single band with a molecular weight (MW) of 91-100 kDa in multiple cell lines. The phosphorylation may result in the higher molecular weight (calculated MW as 80-86 kDa).
Full Name	Enhancer of zeste homolog 2 (Drosophila)
Synonyms	Enhancer of zeste homolog 2, ENX 1, ENX-1, EZH1, EZH2, KMT6, Lysine N methyltransferase 6
Tested Reactivity	Human, mouse, rat
Cited Reactivity	Human, mouse, rat, pig
Class	Polyclonal
Type	Antibody
Immunogen	EZH2 fusion protein
Calculated Molecular Weight	751 aa, 86 kDa
Observed Molecular Weight	90-102 kDa
Gene ID	2146
GenBank Accession Number	BC010858
Gene Symbol	EZH2
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive IP Detected	HepG2 cells
Positive IF Detected	HepG2 cells
Positive FC Detected	HepG2 cells

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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