GAD65 Polyclonal Antibody

CAT#: NEM-K003

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Overview Specification

Target	GAD65
Cell Type	GABAergic neurons
Host	Rabbit
Isotype	IgG
Applications	WB, IP, IHC, IF, ELISA
Reactivity	Human, mouse, rat
Conjugate	Unconjugated
Keywords	GABAergic neurons; Rabbit; IgG; WB, IP, IHC, IF, ELISA

Product Information	It targets GAD65 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
Background Information	GAD2, also named as GAD65, belongs to the group II decarboxylase family. GAD2 catalyzes the production of GABA. It is responsible for the synthesis of the essential neurotransmitter gamma-aminobutyric acid (GABA) from L-glutamic acid. GAD2 is expressed in nervous and endocrine systems and are thought to be involved in synaptic transmission and INS secretion. Autoantibodies against GAD2 may serve as markers for type I diabetes. Many individuals suffering from an adult onset disorder known as Stiff Person Syndrome (SPS) also express autoantibodies to GAD2. The antibody is specific to GAD2.
Synonyms	GAD 65, GAD2, GAD65, Glutamate decarboxylase 2
Full Name	Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Tested Reactivity	Human, mouse, rat
Type	Antibody
Class	Polyclonal
Immunogen	Peptide
Calculated Molecular Weight	65 kDa
Observed Molecular Weight	65 kDa
GenBank Accession Number	NM_000818
Gene ID	2572
Gene Symbol	GAD2
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	Mouse brain tissue, rat brain tissue
Positive IP Detected	Mouse brain tissue
Positive IF Detected	HeLa cells

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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