Genomics Analysis for Brain Tumors

Genomic profiling plays a key role in the diagnosis, grading and personalized therapy of brain tumors. Alfa Cytology offers specialized brain tumor genomics analysis services to our clients to identify DNA alterations that drive tumor progression and uncover genetic changes in specific genes.

Overview of Genomics

Genomics encompasses the comprehensive study of an organism's entire genome, including copy number alterations, single nucleotide variants (SNV), DNA structural variants, gene-fusion events, etc. With the evolution of next-generation sequencing (NGS) technologies, cancer genomics analysis has advanced from the study of a few genes to whole-genome and even multi-omics analysis.

Fig.1 Recent advances in spatial genomics and spatial chromatin organization profiling, and their potential application to precision oncology. (Akhoundova D., & Rubin MA, 2017)

Applications of Genomics in Brain Tumors

Genomic analysis is pivotal in advancing brain tumor basic research and plays a significant role in both diagnosis innovation and potential therapeutic development.

Barin Tumor Basic Research
Genomics analysis of brain tumors helps identify and catalog genetic alterations that drive tumor progression, empowering researchers to systematically investigate tumor etiology and phenotypic impacts.
Brain Tumor Diagnosis
Brain tumors derived from various sites, cell types and genetic mutations may demonstrate distinct patterns. Early diagnosis through genomics enables molecularly precise identification of brain tumors, which provides guidance on drug selection and optimizes the efficacy of personalized therapies.
Therapeutic Development of Brain Tumors
Genomics accelerates the discovery and advancement of novel brain tumor drugs by identifying potential therapeutic targets and biomarkers. Moreover, genomic profiling provides profound insights into brain tumor heterogeneity, which empowers personalized therapies guided by targeted approaches.

Our Services

Alfa Cytology specializes in high-throughput whole genome sequencing and whole exome sequencing services for brain tumors, utilizing cutting-edge next-generation sequencing technologies. Our expertise lies in elucidating the extensive genetic details of brain tumors, encompassing mutations in both coding and non-coding regions, structural variants and copy number alterations.

Basic Analysis

The basic genomics services we provide are tailored to brain tumor research.

Sequencing data summary and data quality assessment.
Comparison of reference genome and annotation statistics.
SNV/InDel/CNV/SV/TMB detection and classification analysis.
SNV/InDel locus filtering and prioritization.
Screening of susceptibility genes and driver genes.
High-frequency mutation gene statistics and pathway enrichment analysis.
Brain tumor mutation characterization and mutation mapping analysis.

Advanced Analysis

Advanced genomics services are offered by integrating various innovative genome sequencing technologies such as whole genome sequencing, targeted panel sequencing, fluorescence in situ hybridization (FISH), etc. Utilizing our cutting-edge genomics services, we assist our clients in exploring the intricate genetic composition of organisms or specific biological samples.

High-frequency CNV analysis.
Fusion gene detection.
Brain tumor purity and ploidy analysis.
Heterozygous deletion analysis.
Integrated analysis of clinical data.

Workflow of Genomics Analysis for Brain Tumors

Sample Preparation

Genomic Sequencing

Library Construction

Data Analysis

Advantages of Our Genomics Analysis

Capable of detecting copy number variations and epigenetic profiles at the chromosomal arm level.
Providing a comprehensive and cost-effective analysis of genetic alterations in brain tumor samples, encompassing copy number variations, epigenetic modifications, and single nucleotide variants (SNVs).
Reveal potentially oncogenic chromosomal translocations, along with gene deletions and mutations that lead to the development of specific types of brain tumors.
Billions of different DNA fragments can be read simultaneously with our next-generation sequencing technology.

Contact Us

The extensive data offered by Alfa Cytology allows you to reveal precise genetic alterations that drive brain tumor advancement and provides clinicians with personalized therapeutic strategies. Contact our staff to explore how we can assist you with your brain tumor genomic research.

Reference

Akhoundova D., & Rubin MA. (2022). Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the future[J]. Cancer cell. 40(9), 920–938.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.