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Human 2B4/CD244/SLAMF4 Protein

Human 2B4/CD244/SLAMF4 Protein

CAT#: ICP-A001

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Overview Specification

Species	Human
Tag	C-His
Expression Systems	Expi293
Keywords	Human; C-His; Expi293

Synonyms	2B4; CD244 antigen; CD244; h2B4; NAIL; NKR2B4; Nmrk; SLAMF4
Background	2B4 (CD244) is expressed by memory-phenotype CD8 T cells and all-natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 is conserved in humans and mice, and several reports have linked 2B4 with the activation of lymphocytes. Engagement of 2B4 on NK cell surfaces with specific antibodies or CD48 can trigger cell-mediated cytotoxicity, interferon γ secretion, phosphoinositol turnover, and NK cell invasiveness.
Source	Recombinant Human 2B4/CD244/SLAMF4 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Cys22-Arg221.
Molecular Weight	The protein has a predicted MW of 23.1 kDa. Due to glycosylation, the protein migrates to 45-70 kDa based on Tris-Bis PAGE result.
Endotoxin	Less than 1 EU per μg by the LAL method.
Purity	>95% as determined by Tris-Bis PAGE. >95% as determined by HPLC.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage	-20 to -80℃ for 12 months as supplied from the date of receipt. -20 to -80℃ for 3-6 months in an unopened state after reconstitution. 2-8℃ for 2-7 days after reconstitution.
Notes	Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid freeze-thaw cycles.

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