Human PVRIG Protein

CAT#: ICP-A021

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Overview Specification
Species Human
Tag C-mFc
Expression Systems Expi293
Keywords Human; C-mFc; Expi293
Synonyms C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1
Background Human PVRIG (poliovirus receptor-related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Source Recombinant Human PVRIG Protein is expressed from Expi293 with mFc tag at the C-terminal. It contains Thr41-Asp171.
Molecular Weight The protein has a predicted MW of 39.6 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result.
Endotoxin Less than 1 EU per μg by the LAL method.
Purity >95% as determined by Tris-Bis PAGE.
>95% as determined by HPLC.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage -20 to -80℃ for 12 months as supplied from the date of receipt.
-20 to -80℃ for 3-6 months in an unopened state after reconstitution.
2-8℃ for 2-7 days after reconstitution.
Notes Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid freeze-thaw cycles.
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