MOG Polyclonal Antibody

CAT#: OLD-D004

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Overview Specification

Target	MOG
Cell Type	Oligodendrocytes
Host	Rabbit
Isotype	IgG
Applications	WB, IHC, IF, ELISA
Reactivity	Human, Mouse, Rat
Conjugate	Unconjugated
Keywords	Oligodendrocytes; Rabbit; IgG; WB, IHC, IF, ELISA

Product Information	It targets MOG in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
Background Information	Myelin/oligodendrocyte glycoprotein (MOG), a 23-28 kDa glycoprotein, a myelin antigen at the outer surface of the central nervous system (CNS) myelin sheath, which may trigger T-cell as well as B-cell responses. It therefore constitutes a pivotal target for autoimmune responses, which result in inflammation and also demyelination in the CNS. Its presence on the outer- most lamellae of mature CNS myelin and its late appearance during myelinogenesis suggest that it contributes to myelin maturation or maintenance. 10 isoforms of MOG produced by alternative splicing have been described, and heterodimers may be formed between the different isoforms. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7), a neurological disabling sleep disorder characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Role of MOG in the pathogenesis of multiple sclerosis (MS) has been reported but remains to be clarified.
Full Name	Myelin oligodendrocyte glycoprotein
Synonyms	MOG, MOGIG 2, myelin oligodendrocyte glycoprotein
Tested Reactivity	Human, mouse, rat
Cited Reactivity	Human, mouse
Class	Polyclonal
Type	Antibody
Immunogen	MOG fusion protein
Calculated Molecular Weight	295 aa, 34 kDa
Observed Molecular Weight	25-28 kDa
Gene ID	4340
GenBank Accession Number	BC035938
Gene Symbol	MOG
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	Mouse brain tissue, rat brain tissue
Positive IHC Detected	Mouse brain tissue

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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