NEUROD1 Polyclonal Antibody

CAT#: NSC-P015

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Overview Specification

Target	NEUROD1
Cell Type	NSCs
Host	Rabbit
Isotype	IgG
Applications	WB, IP, IHC, IF, ELISA
Reactivity	Human, mouse, rat
Conjugate	Unconjugated
Keywords	NSCs; Rabbit; IgG; WB, IP, IHC, IF, ELISA

Product Information	It targets NEUROD1 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
Background Information	NeuroD is a member of the basic helix-loop-helix (bHLH) family of transcription factors. The basic helix-loop-helix (bHLH) proteins are transcription factors that are required for several aspects of development, including cell type determination, terminal differentiation and sex determination. Members of the myogenic determination family, MyoD, myf5, myogenin and MRF4, all have bHLH domains.These proteins function by forming heterodimers with E-proteins and binding to the canonical E-box sequence CANNTG. Neuro D is expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation into mature neurons. Moreover, ectopic expression of Neuro D in Xenopus embryos induces premature differentiation of neuronal precursors and Neuro D can convert presumptive epidermal cells into neurons.The lack of NeuroD in the brain results in severe defects in development. Human mutations have been linked to a number of types of diabetes including type I diabetes mellitus and maturity-onset diabetes of the young. The calculated molecular weight of NEUROD1 is 39 kDa, but the modified NEUROD1 protein is about 45-50 kDa.
Synonyms	BETA2, BHF 1, bHLHa3, NEUROD, NEUROD1, neurogenic differentiation 1
Full Name	Neurogenic differentiation 1
Tested Reactivity	Human, mouse, rat
Cited Reactivity	Human, mouse, rat
Class	Polyclonal
Type	Antibody
Immunogen	NEUROD1 fusion protein
Calculated Molecular Weight	356 aa, 40 kDa
Observed Molecular Weight	50 kDa
Gene ID	4760
GenBank Accession Number	BC009046
Gene Symbol	NEUROD1
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	Y79 cells
Positive IP Detected	Y79 cells
Positive IHC Detected	Rat brain tissue, human pancreas cancer tissue, mouse brain tissue
Positive IF Detected	Mouse brain tissue

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