NEUROD1 Polyclonal Antibody
CAT#: NSC-P015
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Overview
Specification
| Target
|
NEUROD1 |
| Cell Type
|
NSCs |
| Host
|
Rabbit |
| Isotype
|
IgG |
| Applications
|
WB, IP, IHC, IF, ELISA |
| Reactivity
|
Human, mouse, rat |
| Conjugate
|
Unconjugated |
| Keywords
|
NSCs; Rabbit; IgG; WB, IP, IHC, IF, ELISA |
| Product Information
|
It targets NEUROD1 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples. |
| Background Information
|
NeuroD is a member of the basic helix-loop-helix (bHLH) family of transcription factors. The basic helix-loop-helix (bHLH) proteins are transcription factors that are required for several aspects of development, including cell type determination, terminal differentiation and sex determination. Members of the myogenic determination family, MyoD, myf5, myogenin and MRF4, all have bHLH domains.These proteins function by forming heterodimers with E-proteins and binding to the canonical E-box sequence CANNTG. Neuro D is expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation into mature neurons. Moreover, ectopic expression of Neuro D in Xenopus embryos induces premature differentiation of neuronal precursors and Neuro D can convert presumptive epidermal cells into neurons.The lack of NeuroD in the brain results in severe defects in development. Human mutations have been linked to a number of types of diabetes including type I diabetes mellitus and maturity-onset diabetes of the young. The calculated molecular weight of NEUROD1 is 39 kDa, but the modified NEUROD1 protein is about 45-50 kDa. |
| Synonyms
|
BETA2, BHF 1, bHLHa3, NEUROD, NEUROD1, neurogenic differentiation 1 |
| Full Name
|
Neurogenic differentiation 1 |
| Tested Reactivity
|
Human, mouse, rat |
| Cited Reactivity
|
Human, mouse, rat |
| Class
|
Polyclonal |
| Type
|
Antibody |
| Immunogen
|
NEUROD1 fusion protein |
| Calculated Molecular Weight
|
356 aa, 40 kDa |
| Observed Molecular Weight
|
50 kDa |
| Gene ID
|
4760 |
| GenBank Accession Number
|
BC009046 |
| Gene Symbol
|
NEUROD1 |
| Form
|
Liquid |
| Purification Method
|
Antigen affinity purification |
| Storage Buffer
|
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions
|
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage. |
| Positive WB Detected
|
Y79 cells |
| Positive IP Detected
|
Y79 cells |
| Positive IHC Detected
|
Rat brain tissue, human pancreas cancer tissue, mouse brain tissue |
| Positive IF Detected
|
Mouse brain tissue |
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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