Nurr1/NR4A2 Polyclonal Antibody

CAT#: NEM-K008

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Overview Specification

Target	Nurr1/NR4A2
Cell Type	Dopaminergic neurons
Host	Rabbit
Isotype	IgG
Applications	WB, IHC, IF, ChIP, ELISA
Reactivity	Human, mouse, rat
Conjugate	Unconjugated
Keywords	Dopaminergic neurons; Rabbit; IgG; WB, IHC, IF, ChIP, ELISA

Product Information	It targets Nurr1/NR4A2 in WB, IHC, IF, ChIP, ELISA applications and shows reactivity with human samples.
Background Information	NR4A2 belongs to the orphan nuclear receptor (NR) family referred to as NR4A family, which have been implicated in cell cycle regulation, apoptosis, inflammation, metabolism and more recently in carcinogenesis [PMID:22583411]. NR4A2 also has a role in the expression of several proteins that are necessary for the synthesis and regulation of DA, such as tyrosine hidroxilase, DA transporter, vesicular monoamine transporter 2, and cRET [PMID:22294735]. Act as a transcriptional regulator, NR4A2 is essential for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons [PMID: 17184956].
Synonyms	HZF 3, NOT, NR4A2, NURR1, Nurr1/NR4A2, Orphan nuclear receptor NURR1, RNR1, TINUR
Full Name	Nuclear receptor subfamily 4, group A, member 2
Tested Reactivity	Human
Type	Antibody
Class	Polyclonal
Immunogen	Nurr1/NR4A2 fusion protein
Calculated Molecular Weight	66 kDa
Observed Molecular Weight	66 kDa
GenBank Accession Number	BC009288
Gene ID	4929
Gene Symbol	NR4A2
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	A431 cells, fetal human brain tissue, SH-SY5Y cells, COLO 320 cells
Positive IHC Detected	Human gliomas tissue
Positive IF Detected	HepG2 cells

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