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PE-Labeled Human EGFR VIII Protein

PE-Labeled Human EGFR VIII Protein

CAT#: CAR-T013

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Overview Specification

Species	Human
Tag	C-His-Avi
Expression Systems	Expi293
Keywords	Human; C-His-Avi; Expi293

Synonyms	ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2
Background	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.
Source	Recombinant PE-Labeled Human EGFRVIII Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Leu25-Ser378.
Molecular Weight	The protein has a predicted MW of 41.6 kDa same as Tris-Bis PAGE result.
Endotoxin	Less than 1EU per μg by the LAL method.
Purity	>95% as determined by Tris-Bis PAGE.
Formulation	Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Please dilute to the desired concentration according to the concentration of the solution shown on the product label.
Storage	Valid for 12 months from date of receipt when stored at -80℃.
Notes	Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles.

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