| Product Information
|
The immunogen of SMARCA4/BRG1 Fusion Protein expressed in E. coli. |
| Background Information
|
SMARCA4, also named as BAF190A, BRG1, SNF2B and SNF2L4, belongs to the SNF2/RAD54 helicase family. SMARCA4 is a transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. It is a component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. It is also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. |
| Synonyms
|
ATP dependent helicase SMARCA4, BAF190, BAF190A, BRG1, BRG1 associated factor 190A, hSNF2b, Protein brahma homolog 1, Protein BRG 1, SMARCA4, SMARCA4/BRG1, SNF2, SNF2 BETA, SNF2B, SNF2L4, SNF2LB, SWI2, Transcription activator BRG1 |
| Full Name
|
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
| Tested Reactivity
|
Human, mouse, rat |
| Cited Reactivity
|
Human, mouse, bovine, zebrafish |
| Class
|
Polyclonal |
| Type
|
Antibody |
| Immunogen
|
SMARCA4/BRG1 fusion protein |
| Calculated Molecular Weight
|
1647 aa, 185 kDa |
| Observed Molecular Weight
|
185 kDa |
| Gene ID
|
6597 |
| GenBank Accession Number
|
BC150298 |
| Gene Symbol
|
SMARCA4 |
| Form
|
Liquid |
| Purification Method
|
Antigen affinity purification |
| Storage Buffer
|
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions
|
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage. |
| Positive WB Detected
|
HepG2 cells, mouse brain tissue, rat brain tissue, human placenta tissue, HeLa cells |
| Positive IP Detected
|
HeLa cells |
| Positive IHC Detected
|
Human colon cancer tissue, human lung cancer tissue, mouse kidney tissue, human breast cancer tissue, human gliomas tissue |
| Positive IF Detected
|
HepG2 cells, HEK-293 cells, Hela cells |
