SOX2 Polyclonal Antibody

CAT#: OLD-D006

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Overview Specification

Target	SOX2
Cell Type	Oligodendrocytes
Host	Rabbit
Isotype	IgG
Applications	WB, IHC, IF, FC, ELISA
Reactivity	Human, Mouse, Rat, Zebrafish
Conjugate	Unconjugated
Keywords	Oligodendrocytes; Rabbit; IgG; WB, IHC, IF, FC, ELISA

Product Information	It targets SOX2 in WB, IHC, IF, FC, ELISA applications and shows reactivity with human, mouse, rat, zebrafish samples.
Background Information	BackgroundSRY (sex determining region Y)-box 2 is a transcription factor involved in neural stem cell maintenance and has been used in somatic cell reprogramming. What is the molecular weight of Sox2?34 kDa. Sox2 is an intronless gene encoding xx amino acids including HMG (High-mobility group) box domains that can bind to DNA. What is the tissue specificity of Sox2 In embryonic stem cells, Sox2 is highly expressed and is essential in self-renewal. In the developing embryo, Sox2 is found in the neural tube and then in the developing eye and central nervous system (CNS). This expression is highly conserved across organisms (PMID: 25126380; PMID: 8625802).In adult tissues Sox2 is expressed in neural progenitor cells, which as multipotent cells can both self-renew and differentiate into neurons, astroglia, and oligodendroglia. It maintains their stem cell phenotype and is a useful marker of early neural stem cells (PMID: 16139372). What is the role of Sox2 in pluripotency?Sox2 acts as part of the LIF (Leukemia inhibitory factor) pathway, activated via JAK-STAT signaling to form complexes with other transcription factors such as Oct4 that bind to DNA and work to control pluripotency. Sox2 was described as one of the four original factors that are key to the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) (PMID: 16904174). What is the role of Sox2 in cancer?The ability to control pluripotency means dysregulation of Sox2 can lead to uncontrolled proliferation. In many different cancers, Sox2 has been associated with the metastasis and growth of tumors, mostly due to overexpression (PMID: 28388544). The increased levels of Sox2 RNA and protein in tumor tissue highlight it as a potential therapeutic target (PMID: 25114775).
Full Name	SRY (sex determining region Y)-box 2
Synonyms	ANOP3, MCOPS3, SOX2, Transcription factor SOX 2
Tested Reactivity	Human, mouse, rat, zebrafish
Cited Reactivity	Human, mouse, rat, goat, pig
Class	Polyclonal
Type	Antibody
Immunogen	SOX2 fusion protein
Calculated Molecular Weight	34 kDa
Observed Molecular Weight	34-40 kDa
Gene ID	6657
GenBank Accession Number	BC013923
Gene Symbol	SOX2
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	HEK-293 cells
Positive IHC Detected	Human lung cancer tissue, human gliomas tissue, mouse brain tissue, mouse embryo tissue
Positive IF Detected	mouse brain tissue, human embronic stem cells, Zebrafish tissue, mouse olfactory epithelium tissue, NCCIT cell, mouse embryo tissue

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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