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VAMP2 Polyclonal Antibody

VAMP2 Polyclonal Antibody

CAT#: NEM-K014

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Overview Specification

Target	VAMP2
Cell Type	Dopaminergic, GABAergic neurons
Host	Rabbit
Isotype	IgG
Applications	WB, IHC, IF, ELISA
Reactivity	Human, mouse, rat
Conjugate	Unconjugated
Keywords	Dopaminergic, GABAergic neurons; Rabbit; IgG; WB, IHC, IF, ELISA

Product Information	It targets VAMP2 in WB, IHC, IF, Blocking, ELISA applications and shows reactivity with human, mouse, rat samples.
Background Information	VAMP2 (vesicle-associated membrane protein 2), also named as synaptobrevin 2, is a member of the SNARE (soluble NSF-attachment protein receptor) family proteins. Characterized by a common sequence called the SNARE motif, SNARE proteins are involved in membrane fusion and vesicular transport (PMID: 11252968). VAMP2, with a molecular mass of 15-19 kDa, consists of a short N-terminal sequence, a SNARE motif, and a C-terminal transmembrane region. It is required for fast calcium-triggered synaptic vesicle fusion. VAMP2 forms a stable complex with STX1 (syntaxin 1) and SNAP25 (synaptosomal-associated protein 25) during synaptic vesicle fusion (PMID: 16793874). It also forms a distinct complex with synaptophysin. VAMP2 is expressed in nervous system and some non-neuronal tissues, such as skeletal muscle (PMID: 18570252).
Synonyms	SYB2, Synaptobrevin 2, VAMP 2, VAMP2
Full Name	Vesicle-associated membrane protein 2 (synaptobrevin 2)
Tested Reactivity	Human, mouse, rat
Type	Antibody
Class	Polyclonal
Immunogen	VAMP2 fusion protein
Calculated Molecular Weight	13 kDa
Observed Molecular Weight	19 kDa
GenBank Accession Number	BC002737
Gene ID	6844
Gene Symbol	VAMP2
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	Mouse brain tissue, fetal human brain tissue, rat brain tissue
Positive IHC Detected	Mouse brain tissue, human skeletal muscle tissue

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