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VMAT2 Polyclonal Antibody

VMAT2 Polyclonal Antibody

CAT#: NEM-K015

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Overview Specification

Target	VMAT2
Cell Type	Dopaminergic neurons
Host	Rabbit
Isotype	IgG
Applications	WB, IHC, IF, ELISA
Reactivity	Human, mouse, rat
Conjugate	Unconjugated
Keywords	Dopaminergic neurons; Rabbit; IgG; WB, IHC, IF, ELISA

Product Information	The immunogen of is VMAT2 Fusion Protein expressed in E. coli.
Background Information	VMAT2 is a vesicular monoamine transporter that is responsible for the uptake and storage of monoamines (dopaine, epinephrine, histamine and serotonin) in neurons, endocrine cells, and tumors deriving from these cells. Histamine-producing endocrine tumors (gastric carcinoids) expressed VMAT2 almost exclusively, thus VMAT2 is useful in classification of neuroendocrine tumors. Reduced expression of VMAT2 has often been observed in Parkinson's diseased (PD) brain, and detection of VMAT2 can be used to reflect the 4-(2-aminoethyl)benzene-1,2-diol neuron loss and predict the disease process. Several forms of VMAT2 can be observed upon the glycosylation: 45 kDa band corresponds to the native (deglycosylated) form, and the 55 and 75 kDa bands to glycosylated forms (PMID: 17582657).
Synonyms	Monoamine transporter, SLC18A2, SVAT, SVMT, VAT2, Vesicular amine transporter 2, VMAT2
Full Name	Solute carrier family 18 (vesicular monoamine), member 2
Tested Reactivity	Human
Type	Antibody
Class	Polyclonal
Immunogen	VMAT2 fusion protein
Calculated Molecular Weight	514 aa, 56 kDa
Observed Molecular Weight	45-55 kDa
GenBank Accession Number	BC108928
Gene ID	6571
Gene Symbol	SLC18A2
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.
Positive WB Detected	SGC-7901 cells
Positive IHC Detected	Mouse brain tissue, rat brain tissue

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