Therapeutic Antibody Development for Breast Cancer

Therapeutic Antibody Development for Breast Cancer

Antibody therapies are a large and rapidly evolving class of drugs that can provide significant health benefits. Alfa Cytology offers therapeutic antibody development services, providing clients with different forms of therapeutic antibodies for breast cancer treatment.

Introduction to Antibody for Breast Cancer Therapy

Breast cancer (BC) is a highly heterogeneous malignant tumor occurring in breast epithelial tissue, which is more common in women. The systemic treatment of BC has initially formed a mature system including chemotherapy, targeted therapy, endocrine therapy, neoadjuvant therapy, surgery, and immunotherapy. Antibody-based therapeutic strategies have emerged as an established treatment option for bladder cancer over the past decade.

Fig.1 Monoclonal antibodies in breast cancer. (Behl A., et al. 2023)Fig.1 Monoclonal antibodies in breast cancer. (Behl A., et al. 2023)

Antibody Development for Breast Cancer

Target NCT Therapeutics Phase
PD-1/PD-L1 NCT05422794 Pembrolizumab
NCT03971409 Avelumab
NCT03281954 Atezolizumab
NCT02826434 Durvalumab
CTLA-4 NCT04606472 SI-B003 (a CTLA-4/PD-1 bispecific antibody)
NCT05620134 JK08 (CTLA-4 targeting IL-15 antibody fusion protein)

Our Services

Alfa Cytology is equipped with extensive expertise in this field and is committed to assisting you and your teams in developing safe and efficacious therapeutic antibodies with utmost efficiency. We offer a one-stop service for the development of therapeutic antibodies for the treatment of breast cancer.

Therapeutic Monoclonal Antibody Development Platform

  • Antigen Identification
  • Hybridoma Technology
  • Recombinant Production

Therapeutic Antibody Fragment Development Platform

  • Antibody Selection and Cloning
  • Expression System Preparation
  • Antibody Fragment Expression

Therapeutic Bispecific Antibody (BsAb) Development Platform

  • Identify Two Distinct Antibody Sequences
  • Design the Bispecific Antibody Format
  • Engineer the Bispecific Antibody Construct

Antibody-drug Conjugates Development Platform

  • Monoclonal Antibody Development
  • Cytotoxin Synthesis
  • Linker Design and Preparation

Bispecific Antibody-drug Conjugates (BsADCs) Development Platform

  • Bispecific Antibody Generation
  • Linker-Drug Conjugation
  • Optimize the Drug-to-antibody Ratio

Breast Cancer Single-domain Antibody Development Platform

  • Immunization and Library Generation
  • Phage Display
  • Single-domain Antibody Selection and Characterization

As a trusted partner in therapeutic antibody generation, Alfa Cytology is fully dedicated to contributing to the success of our customers' breast cancer therapeutic projects. We are committed to supporting your therapeutic antibody discovery project and gain access to the most comprehensive solution for developing your antibody drug candidate. If you are interested in our service, please contact us.

Reference

  1. Behl A., Wani Z. A., and et al. Monoclonal antibodies in breast cancer: A critical appraisal. Crit Rev Oncol Hematol. 2023, 183: 103915.
All our services are exclusively intended for preclinical research purposes. They are not intended for diagnostic, therapeutic, or patient management applications.