PI3K/AKT/mTOR Pathway Inhibitor Development

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is a central regulator of cellular processes such as proliferation, growth, differentiation, and survival. At Alfa Cytology, we specialize in developing novel molecules targeting the PI3K/AKT/mTOR pathway for breast cancer therapy.

Introduction to PI3K/AKT/mTOR Pathway Inhibitor for Breast Cancer

The PI3K/AKT/mTOR pathway is a highly interconnected signaling cascade that plays a crucial role in regulating various cellular functions. It is initiated by the activation of PI3K, a lipid kinase that phosphorylates the membrane lipid phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 acts as a second messenger, recruiting and activating the serine/threonine kinase AKT. Activated AKT then phosphorylates a myriad of downstream effectors, including the mTOR complex.

Fig. 1 Signaling by the PI3K/AKT/mTOR pathway and the respective inhibitors. (Li H., et al. 2021)

PI3K/AKT/mTOR Pathway Inhibitor Development for Breast Cancer

In breast cancer, the PI3K/AKT/mTOR pathway is frequently hyperactivated due to a variety of genetic and epigenetic alterations. The overactivation of this pathway contributes to the hallmarks of cancer, such as uncontrolled cell proliferation, evasion of apoptosis, and metabolic reprogramming. Moreover, the PI3K/AKT/mTOR pathway has been implicated in the development of resistance to various breast cancer therapies, including chemotherapy, targeted agents, and endocrine therapy. This highlights the urgent need for the development of novel therapeutic strategies that effectively target this critical signaling pathway.

Our Services

As a leading preclinical CRO, Alfa Cytology is committed to advancing the development of innovative cancer therapies, including PI3K/AKT/mTOR targeted inhibitors for breast cancer. Our state-of-the-art facilities and multidisciplinary team of experts provide comprehensive services to support the entire drug development process, from target identification and validation to preclinical studies and biomarker development.

Our Therapeutics Development Platform for PI3K/AKT/mTOR Inhibitors Development

Alfa Cytology provides development services for PI3K/AKT/mTOR inhibitors, covering drug design, screening, and efficacy research to find ideal drug candidates for you and accelerate preclinical research on your breast cancer therapeutics. To learn more about our capabilities in PI3K/AKT/mTOR inhibitor development for breast cancer or to discuss potential collaborative opportunities, please don't hesitate to contact us.